Protein function predictions articles within Nature

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• Article
  13 September 2023 | Open Access

  Uncovering new families and folds in the natural protein universe

  The extent to which the AlphaFold database has structurally illuminated proteins that are challenging to annotate for function or putative biological role using standard homology-based approaches at high predicted accuracy is investigated.

  • Janani Durairaj
  • , Andrew M. Waterhouse
  •  & Joana Pereira

• Letter | 10 September 2018

  Experimental and computational framework for a dynamic protein atlas of human cell division

  Quantitative live-cell imaging provides a dynamic protein atlas of mitosis.

  • Yin Cai
  • , M. Julius Hossain
  •  & Jan Ellenberg

• Article | 16 May 2018

  Mutant phenotypes for thousands of bacterial genes of unknown function

  A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function.

  • Morgan N. Price
  • , Kelly M. Wetmore
  •  & Adam M. Deutschbauer

• Letter | 09 April 2018

  Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

  The Cdc48 adaptor Vms1 is a peptidyl-tRNA hydrolase that cooperates with the ribosome quality control complex to catalyse the removal of nascent polypeptides from stalled ribosomes.

  • Rati Verma
  • , Kurt M. Reichermeier
  •  & Raymond J. Deshaies

• Letter | 22 December 2016

  New CRISPR–Cas systems from uncultivated microbes

  Using a metagenomic approach, three types of CRISPR–Cas systems have been discovered in uncultivated bacterial and archaeal hosts from a variety of different environments.

  • David Burstein
  • , Lucas B. Harrington
  •  & Jillian F. Banfield

• Letter | 17 November 2014

  Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

  Time--β bound to substrate DNA as it inserts 8-oxo-dGTP opposite either cytosine or adenine.

  • Bret D. Freudenthal
  • , William A. Beard
  •  & Samuel H. Wilson

• Article | 08 October 2014

  Structure and immune recognition of trimeric pre-fusion HIV-1 Env

  A crystal structure of the human immunodeficiency virus Env trimer, used by the virus to infect cells, is determined here; the new structure, which shows the pre-fusion form of Env, increases our understanding of the fusion mechanism and of how the conformation of Env allows the virus to evade the immune response.

  • Marie Pancera
  • , Tongqing Zhou
  •  & Peter D. Kwong

• Letter | 22 September 2013

  Discovery of new enzymes and metabolic pathways by using structure and genome context

  Pathway docking (in silico docking of metabolites to several enzymes and binding proteins in a metabolic pathway) enables the discovery of a catabolic pathway for the osmolyte trans-4-hydroxy-l-proline betaine.

  • Suwen Zhao
  • , Ritesh Kumar
  •  & Matthew P. Jacobson