Protein analysis articles from across Nature Portfolio

Reynolds and colleagues examine a biochemically-mediated epistatic interaction between metabolic enzymes involved in folate metabolism and show that biochemical coupling shapes the range of enzyme activities sufficient to rescue cell growth.

A proteome-scale analysis of human coding variants reveals constrained sites in thousands of domains. This highlights key structural or functional residues, including pathogenic sites, especially when integrated with evolutionary conservation.

This Genome Watch highlights how a tailor-made search through bacterial genomes revealed the widespread presence of a new class of bacterial signalling peptides that lack conventional characteristics.

This study reveals that the production of cobalamin and succinyl-CoA is increased in the anal microbiome of patients with precancerous anal lesions. Testing for these two metabolites significantly improves diagnostic accuracy over standard cytology screening, which suggests potential for enhanced screening strategies for anal cancer.

Newly sequenced organisms present a challenge for protein function prediction, as they lack experimental characterisation. A network-propagation approach that integrates functional network relationships with protein annotations, transferred from well-studied organisms, produces a more complete picture of the possible protein functions.