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| Open AccessHistone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer
The molecular mechanisms underlying androgen production in prostate cancer remain to be explored. Here, the authors reveal an epigenetic mark, K130Ac on H2A, following dual-phosphorylation on SREBP1 promoting de novo androgen synthesis to overcome the pharmacological inhibition of androgen synthesis.
- Thanh Nguyen
- , Dhivya Sridaran
- & Nupam P. Mahajan
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Article
| Open AccessStromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity
Forkhead transcription factor FoxF2 plays a crucial role in the development of organs derived from primitive gut. Here the authors show that reduction of Foxf2 expression in stromal cells is associated with high grade prostate cancer and that increasing prostatic stromal Foxf2 sensitizes prostate cancer to immune checkpoint blockade.
- Deyong Jia
- , Zhicheng Zhou
- & Li Xin
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Article
| Open AccessTUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling
The β-tubulin family protein TUBB4A is highly expressed in cancer but it’s molecular role is unclear. Here, the authors show that TUBB4A is required to protect the nucleus from genomic instability during migration and that it’s over expression promotes cancer progression.
- Song Gao
- , Shuaibin Wang
- & Lizhong Wang
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Article
| Open AccessTNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease
Reduction of systemic autoimmunity using TNF blockers may also reduce inflammatory diseases in other organs. Here, the authors use a patient database and scRNA-seq to link autoimmune diseases to benign prostatic hyperplasia (BPH), and demonstrate that prostatic hyperplasia is reduced by TNF blockers in humans and mice.
- Renee E. Vickman
- , LaTayia Aaron-Brooks
- & Simon W. Hayward
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| Open AccessHyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer
Your paper will be accompanied by the following editor’s summary. Please let us know if there are any inaccuracies: ‘Hyperpolarised ¹³C-MRI is used to image cancer metabolism. Here the authors use this technique in prostate cancer and show that it can differentiate distinct disease states.
- Nikita Sushentsev
- , Mary A. McLean
- & Ferdia A. Gallagher
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| Open AccessAndrogen receptor and MYC equilibration centralizes on developmental super-enhancer
Androgen receptor in prostate cancer (PCa) transcriptionally represses multiple genes including MYC. Here, the authors suggest that increased MYC in response to androgen deprivation contributes to castration-resistant PCa, while decreased MYC may contribute to responses to supraphysiological androgen therapy.
- Haiyang Guo
- , Yiming Wu
- & Steven P. Balk
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| Open AccessInter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets.
- Lauren Brady
- , Michelle Kriner
- & Peter S. Nelson
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| Open AccessIdentification of a Zeb1 expressing basal stem cell subpopulation in the prostate
Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.
- Xue Wang
- , Haibo Xu
- & Helen He Zhu
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| Open AccessAssociation of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms
In prostate cancer, investigating aberrant gene expression may shed light on disease etiology. Here, the authors imputed expression transcriptome-wide for 233,955 European ancestry men, discovering and replicating the associations between prostatic expression for select genes and prostate cancer risk, including the highly prevalent gene fusion partner TMPRSS2. The authors furthermore integrate diverse functional genomic datasets to interpret the epigenetic mechanisms by which the implicated risk variants and genes modulate disease risk.
- Nima C. Emami
- , Linda Kachuri
- & John S. Witte
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| Open AccessRETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer
Treatment of prostate cancer, especially in its advanced stage, is still challenging; therefore, strategies to prevent metastatic dissemination are of great interest. Here the authors reveal a crucial role for liver X receptors in suppressing prostate carcinogenesis and metastatic progression in PTEN-null tumors.
- Anthony Alioui
- , Julie Dufour
- & Silvère Baron
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Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages
The role of cell division modes of basal and luminal epithelial cells in prostate development and tumorigenesis is unclear. Here, the authors show that while luminal cells contribute to development and tumorigenesis via symmetrical divisions, basal cells do so through asymmetric divisions.
- Jia Wang
- , Helen He Zhu
- & Wei-Qiang Gao