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Letter |
Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT
The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytosol interface.
- Melinda M. Diver
- , Leanne Pedi
- & Stephen B. Long
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Letter |
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
These authors identify the human enzyme responsible for menaquinone-4 biosynthesis, a naturally occurring form of vitamin K. They find that UbiA prenyltransferase containing 1, a human homologue of a prenyltransferase gene from Escherichia coli, encodes an enzyme that can convert vitamin K derivatives into menaquinone-4.
- Kimie Nakagawa
- , Yoshihisa Hirota
- & Toshio Okano