Post-traumatic stress disorder articles within Nature Communications

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  • Article
    | Open Access

    Whether fear memories can be attenuated through on demand electrical stimulation remains unclear. Here, the authors demonstrate that fear extinction can be augmented through closed-loop stimulation of the reward system, guided by hippocampal SWRs.

    • Rodrigo Ordoñez Sierra
    • , Lizeth Katherine Pedraza
    •  & Antal Berényi

  • Article
    | Open Access

    Neurostimulation has been proposed as a potential approach for treatment-resistant PTSD. Here in a pilot study the authors show that amygdala theta activity is heightened during aversive and symptomatic experiences in patients with treatment-resistant post-traumatic stress disorder, and reduced following significant clinical improvement associated with closed-loop stimulation.

    • Jay L. Gill
    • , Julia A. Schneiders
    •  & Jean-Philippe Langevin

  • Article
    | Open Access

    Studying the shared genetic etiology of disease can help improve diagnosis and treatment. Here, the authors find evidence for shared genetic and molecular pathophysiology between several common psychiatric and neurodegenerative diseases using results of 25 GWAS and large-scale human brain transcriptomic and proteomic sequencing.

    • Thomas S. Wingo
    • , Yue Liu
    •  & Aliza P. Wingo

  • Article
    | Open Access

    It remains unclear how predictions of future threat affect memory recall, specifically in the case of post-traumatic stress disorder (PTSD). Here, the authors combined computational modeling and brain connectivity analyses to show that individuals with PTSD have exaggerated predictive control and reduced reactive control in a memory suppression task.

    • Giovanni Leone
    • , Charlotte Postel
    •  & Pierre Gagnepain

  • Article
    | Open Access

    PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.

    • Alicia K. Smith
    • , Andrew Ratanatharathorn
    •  & Caroline M. Nievergelt

  • Article
    | Open Access

    Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.

    • Alice Shaam Al Abed
    • , Eva-Gunnel Ducourneau
    •  & Aline Desmedt

  • Article
    | Open Access

    Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

    • Caroline M. Nievergelt
    • , Adam X. Maihofer
    •  & Karestan C. Koenen

  • Article
    | Open Access

    Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is lower in those with more severe symptoms of depression.

    • Sophie E. Holmes
    • , Dustin Scheinost
    •  & Irina Esterlis

  • Article
    | Open Access

    Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.

    • Syed Ahsan Raza
    • , Anne Albrecht
    •  & Oliver Stork

  • Article
    | Open Access

    DICER1 is required for the maturation of miRNAs which regulate expression of thousands of genes. Here the authors show significantly reduced levels of DICER1in individuals having post-traumatic stress disorder and comorbid depression suggestive of a role in the molecular mechanism of the condition.

    • Aliza P. Wingo
    • , Lynn M. Almli
    •  & Kerry J. Ressler

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