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| Open AccessMetabolic fingerprinting on retinal pigment epithelium thickness for individualized risk stratification of type 2 diabetes mellitus
The retina’s role in type 2 diabetes is not well understood. Here, the authors show that retinal pigment epithelium thickness, with its metabolic fingerprints, might offer improved predictability and clinical utility beyond traditional indicators.
- Shaopeng Yang
- , Zhuoting Zhu
- & Wei Wang
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| Open AccessReal-time environmental surveillance of SARS-CoV-2 aerosols
Rapid detection of respiratory pathogens circulating in indoor environments could facilitate improved infection prevention responses. In this proof-of-concept study, the authors develop a pathogen air quality monitor for real-time direct detection of SARS-CoV-2 aerosols and demonstrate its application in rooms of people with SARS-CoV-2 infections.
- Joseph V. Puthussery
- , Dishit P. Ghumra
- & Rajan K. Chakrabarty
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| Open AccessMachine learning prediction of the degree of food processing
Evidence suggests that increased consumption of ultra-processed food has adverse health implications, however, it remains difficult to classify processed food. Here, the authors introduce FPro, a machine learning-based score predicting the degree of food processing.
- Giulia Menichetti
- , Babak Ravandi
- & Albert-László Barabási
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| Open AccessDrivers of SARS-CoV-2 testing behaviour: a modelling study using nationwide testing data in England
SARS-CoV-2 testing rates have varied during the pandemic but the drivers of changes in testing behaviour are unclear. Here, the authors link national testing data from England to indicators of epidemic trends to describe how testing varies according to level of virus transmission, disease susceptibility/severity, public health measures, and risk perception.
- Younjung Kim
- , Christl A. Donnelly
- & Pierre Nouvellet
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| Open AccessData-driven analysis to understand long COVID using electronic health records from the RECOVER initiative
In this study, the authors characterise post-acute sequelae of SARS-CoV-2 (PASC) in two large cohorts based on electronic health records from the USA. They identify a broad range of PASC-related conditions which were only partially replicated across the two cohorts, indicating possible heterogeneity between populations.
- Chengxi Zang
- , Yongkang Zhang
- & Rainu Kaushal
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| Open AccessEffective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children
Dewald et al. combine a non-invasive sampling approach (Lolli-Test) with an RT qPCR-pool testing strategy to screen for SARS-CoV-2 infections in children and use the method for surveillance and infection control in > 4000 school and daycare settings.
- Felix Dewald
- , Isabelle Suárez
- & Florian Klein
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| Open AccessRapid antigen testing as a reactive response to surges in nosocomial SARS-CoV-2 outbreak risk
Healthcare facilities are vulnerable to SARS-CoV-2 introductions and subsequent nosocomial outbreaks. Here, the authors simulate transmission in a long-term care facility with varying containment measures in place and evaluate reactive response with antigen rapid diagnostic testing.
- David R. M. Smith
- , Audrey Duval
- & Laura Temime
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| Open AccessThe risk of indoor sports and culture events for the transmission of COVID-19
Mass gathering events represent a risk for transmission of SARS-CoV-2. Here, the authors describe an experimental indoor test event in which individual contacts were measured and use aerosol and epidemiological modelling to evaluate transmission risks of different types of restrictions in the arena.
- Stefan Moritz
- , Cornelia Gottschick
- & Rafael Mikolajczyk
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| Open AccessTemporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya
The reported burden of SARS-CoV-2 has been relatively low in tropical Africa compared to Europe and the Americas, but estimating true infection rates is challenging. Here, the authors screen blood donors in Kenya for SARS-CoV-2 antibodies and describe spatiotemporal seroprevalence dynamics.
- Ifedayo M. O. Adetifa
- , Sophie Uyoga
- & George M. Warimwe
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| Open AccessThe geometry of clinical labs and wellness states from deeply phenotyped humans
Longitudinal multi-omics measurements are highly valuable in studying heterogeneity in health and disease phenotypes. Here, the authors apply Pareto Task Inference to analyze the clinical lab tests of 3094 individuals and find three wellness states, and one aberrant health state defining this cohort.
- Anat Zimmer
- , Yael Korem
- & Nathan D. Price
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| Open AccessOptimal COVID-19 quarantine and testing strategies
Safely reducing the necessary duration of quarantine for COVID-19 could lessen the economic impacts of the pandemic. Here, the authors demonstrate that testing on exit from quarantine is more effective than testing on entry, and can enable quarantine to be reduced from fourteen to seven days.
- Chad R. Wells
- , Jeffrey P. Townsend
- & Alison P. Galvani
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| Open AccessPost-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
Large-scale population screening can provide insights to levels of ongoing SARS-CoV-2 transmission. Here, the authors report a citywide screening of ~10,000,000 residents of Wuhan and show that SARS-CoV-2 infection prevalence was very low five to eight weeks after the end of lockdown.
- Shiyi Cao
- , Yong Gan
- & Zuxun Lu
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| Open AccessEfficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives
Genetic data from large cohorts of unrelated individuals can be used to create polygenic risk scores, which could be used to predict individual risk of developing a specific disease. Here the authors show that smaller cohorts of related individuals can provide similarly powerful predictive ability.
- Buu Truong
- , Xuan Zhou
- & S. Hong Lee
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| Open AccessComprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
Developing noninvasive diagnostic biomarkers for lupus nephritis (LN) diagnosis is an important clinical goal. Here the authors identify urinary proteins correlated with active LN and disease severity, which differ across ethnicities but collectively outperform the current clinical method.
- Samantha Stanley
- , Kamala Vanarsa
- & Chandra Mohan