Polycystic ovary syndrome articles from across Nature Portfolio

Metabolic complications are common in patients suffering PCOS, including obesity, insulin resistance and type-2 diabetes. Here the authors show the efficacy of GLP1-based multi-agonists, and superiority of GLP1/E, for managing metabolic complications of PCOS in preclinical models, with improvement also of some reproductive traits.

Polycystic ovary syndrome (PCOS) is a common disorder of unclear aetiology. Although genetic factors contribute to PCOS, they only partially account for its heritability. Here, Stener-Victorin and Deng discuss the evidence that altered epigenetic and developmental programming influence the pathogenesis and familial transmission of PCOS.

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women. Here, Héctor F. Escobar-Morreale reviews the newest advances and limitations of current knowledge regarding PCOS and provides principles for the diagnosis and management of women with PCOS.

Up to one in four women with type 1 diabetes mellitus (T1DM) also have polycystic ovary syndrome (PCOS). Under subcutaneous insulin administration, systemic hyperinsulinism might trigger PCOS in women predisposed to the condition. However, very little is known about the long-term consequences of androgen excess in women with T1DM, and management guidelines are lacking.

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by reproductive and metabolic disturbances. Androgen excess is a hallmark of PCOS, driving many of the phenotypic features. In 2020, several findings highlight altered metabolic pathways as an underlying biological mechanism in PCOS. These findings add to our understanding of the complex interaction between metabolic homeostasis and reproduction.