PML bodies

  • Article
    | Open Access

    FAT10 is an ubiquitin-like modifier that targets proteins to proteasomal degradation. Here, the authors show that FAT10 also regulates SUMO activation in vitro and in cells, providing evidence for functional crosstalk between two ubiquitin-like modifiers.

    • Annette Aichem
    • , Carolin Sailer
    •  & Marcus Groettrup
  • Article
    | Open Access

    Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes promyelocytic leukemia leukemogenesis in transgenic mice.

    • Yuwen Li
    • , Xiaodan Ma
    •  & Guoyu Meng
  • Article
    | Open Access

    The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.

    • Annie M. Sriramachandran
    • , Katrin Meyer-Teschendorf
    •  & R. Jürgen Dohmen