Physiology articles from across Nature Portfolio

Physiology is the branch of the biological sciences that deals with the life-supporting functions and processes of living organisms or their parts. The study of physiology aims to understand how living things work, which can then aid the treatment of diseases.

Featured

News & Views | 23 March 2023

Astrocytic OxPhos: more than just energy production
- Luis F. Rubio-Atonal
- & Maria S. Ioannou
Nature Metabolism 5, 362-363
News & Views | 22 March 2023

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

Nature Metabolism 5, 368-369
News & Views | 20 March 2023

The basics of base sensing
- Scarlet J. Park
- & William W. Ja
Nature Metabolism 5, 364-365

Latest Research and Reviews

Research | 25 March 2023

Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study
- Leah Rethy
- , Vincenzo B. Polsinelli
- & Jordana B. Cohen
Journal of Human Hypertension, 1-4
Research
25 March 2023 | Open Access

Revealing the diversity of internal body temperature and panting response for feedlot cattle under environmental thermal stress
- M. A. Islam
- , S. Lomax
- & C. E. F. Clark
Scientific Reports 13, 4879
Research
24 March 2023 | Open Access

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice

Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver of male mice, and that deletion of Egr-1 results in increased liver fat accumulation.
- Jing Wu
- , Dandan Bu
- & Chao-Jun Li
Nature Communications 14, 1634
Research
24 March 2023 | Open Access

Clinical significance of serum levels of 14-3-3β protein in patients with stable chronic obstructive pulmonary disease
- Decai Wang
- , Lizong Rao
- & Biwen Mo
Scientific Reports 13, 4861
Research
24 March 2023 | Open Access

GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway
- Guoqiang Fan
- , Yanfei Li
- & Xiaojing Yang
Cell Death & Disease 14, 208
Research | 23 March 2023

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Tsirigotaki et al. unveil how adipokine Leptin induces trimerization of the Leptin receptor to form a cytokine-receptor assembly critical to body weight regulation, immunity, fertility and cancer.
- Alexandra Tsirigotaki
- , Ann Dansercoer
- & Kenneth Verstraete
Nature Structural & Molecular Biology, 1-13

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News and Comment

News & Views | 23 March 2023

Astrocytic OxPhos: more than just energy production

Although astrocytes are largely glycolytic, they catabolize a variety of substrates via oxidative phosphorylation in the mitochondria. In this issue, Mi et al. show that oxidative phosphorylation in astrocytes protects the brain from inflammation and degeneration by degrading excess fatty acids.
- Luis F. Rubio-Atonal
- & Maria S. Ioannou
Nature Metabolism 5, 362-363
Research Highlights | 22 March 2023

CITED1 mediates sex-specific regulation of food intake in hypothalamic neurons
- Olivia Tysoe
Nature Reviews Endocrinology, 1
News & Views | 22 March 2023

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

PCYT2 is an enzyme involved in lipid biosynthesis, and its genetic deficiency in zebrafish, mice and humans causes progressive muscle weakness. Importantly, PCYT2 activity declines in ageing muscles of mice and humans, and PCYT2 gene therapy in aged mice improves muscle strength, suggesting new therapeutic avenues to explore for maintaining muscle health in ageing.

Nature Metabolism 5, 368-369
News & Views | 20 March 2023

The basics of base sensing

Animals need to be able to evaluate environmental pH. Mechanisms that mediate sour taste and acid sensing have been reported across species, but less is known about the detection of high pH. Mi et al. identify the gene alkaliphile, which encodes a high-pH-gated chloride channel in the gustatory system of flies.
- Scarlet J. Park
- & William W. Ja
Nature Metabolism 5, 364-365
Comments & Opinion | 16 March 2023

Prioritize research on human behaviour during extreme heat
- Nicole T. Vargas
- , Zachary J. Schlader
- & Arnagretta Hunter
Nature Human Behaviour, 1-2
News & Views | 15 March 2023

Profiling the Ca²⁺ spark dynamics in live cardiomyocytes

Calcium sparks are the elementary detectable units of calcium release through ryanodine receptors (RyRs). Hou et al. correlate Ca²⁺ sparks with RyR cluster configurations and provide insights into the dynamics of Ca²⁺ release in live cardiomyocytes at baseline and in pathological conditions.
- Laetitia Pereira
- , Almudena Val-Blasco
- & Ana M. Gómez
Nature Cardiovascular Research 2, 225-226

All News & Comment

Physiology articles from across Nature Portfolio

Featured

Astrocytic OxPhos: more than just energy production

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

The basics of base sensing

Latest Research and Reviews

Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study

Revealing the diversity of internal body temperature and panting response for feedlot cattle under environmental thermal stress

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice

Clinical significance of serum levels of 14-3-3β protein in patients with stable chronic obstructive pulmonary disease

GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

News and Comment

Astrocytic OxPhos: more than just energy production

CITED1 mediates sex-specific regulation of food intake in hypothalamic neurons

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

The basics of base sensing

Prioritize research on human behaviour during extreme heat

Profiling the Ca²⁺ spark dynamics in live cardiomyocytes

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