Phosphoproteins are proteins that are phosphorylated, usually by kinases. They may be part of signal transduction cascades in which one kinase phosphorylates one kinase (making it a phosphoprotein) or multiple kinases, to amplify and propagate a cellular signal.

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  • Research Highlights |

    In a recent paper in Cell Research, Yu et al. show that maternally inherited Yes-associated protein (Yap), a co-activator of TEAD family transcription factors, plays a key role in activating embryonic transcription following fertilization in the mouse.

    • Eszter Posfai
    •  & Janet Rossant
    Cell Research 26, 393-394