Phospholipids

Phospholipids are lipids that generally consisting of three components: a diglyceride, a phosphate group and another organic molecule for instances choline to create phosphatidylcholine. Phospholipids are a major component of all cellular membranes and can form bilayers.

Latest Research and Reviews

  • Research |

    Saliakoura et al. find that PLCγ1 is suppressed in hypoxic KRAS-mutant lung cancer cells, which impairs Ca2+ entry into the mitochondria and promotes glycolysis to enhance tumour progression.

    • Maria Saliakoura
    • , Matteo Rossi Sebastiano
    • , Chiara Pozzato
    • , Florian H. Heidel
    • , Tina M. Schnöder
    • , Spasenija Savic Prince
    • , Lukas Bubendorf
    • , Paolo Pinton
    • , Ralph A. Schmid
    • , Johanna Baumgartner
    • , Stefan Freigang
    • , Sabina A. Berezowska
    • , Alessandro Rimessi
    •  & Georgia Konstantinidou
    Nature Cell Biology 22, 1382-1395
  • Research |

    Imaging of phosphatidylcholine, sphingomyelin and their interorganelle lipid transport in live cells, using azido-choline and a spatially limited bioorthogonal tag, suggests that autophagosomal membranes originate from the ER.

    • Tomonori Tamura
    • , Alma Fujisawa
    • , Masaki Tsuchiya
    • , Yuying Shen
    • , Kohjiro Nagao
    • , Shin Kawano
    • , Yasushi Tamura
    • , Toshiya Endo
    • , Masato Umeda
    •  & Itaru Hamachi
  • Research |

    The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether phospholipids, and changes in the abundances of these lipids are associated with altered sensitivity to ferroptosis during cell-state transitions.

    • Yilong Zou
    • , Whitney S. Henry
    • , Emily L. Ricq
    • , Emily T. Graham
    • , Vaishnavi V. Phadnis
    • , Pema Maretich
    • , Sateja Paradkar
    • , Natalie Boehnke
    • , Amy A. Deik
    • , Ferenc Reinhardt
    • , John K. Eaton
    • , Bryan Ferguson
    • , Wenyu Wang
    • , Joshua Fairman
    • , Heather R. Keys
    • , Vlado Dančík
    • , Clary B. Clish
    • , Paul A. Clemons
    • , Paula T. Hammond
    • , Laurie A. Boyer
    • , Robert A. Weinberg
    •  & Stuart L. Schreiber
    Nature 585, 603-608
  • Research
    | Open Access

    The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.

    • Yuta Ogasawara
    • , Jinglei Cheng
    • , Tsuyako Tatematsu
    • , Misaki Uchida
    • , Omi Murase
    • , Shogo Yoshikawa
    • , Yuki Ohsaki
    •  & Toyoshi Fujimoto

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