Pharmacogenomics

Pharmacogenomics is the study of how genetic variation influences responses to drugs. This includes how genetic variants affect drug metabolism, efficacy and toxicity, with the goal of improving and personalizing drug therapy.

Latest Research and Reviews

News and Comment

  • Editorial |

    Given that it is based on heredity and has the ability to trace connections, genetics as a scientific discipline should be among those most attuned to diversity and global perspectives. Indigenous communities and scientists have much to contribute to genetics research, and they are making their voices heard. We celebrate these essential members of our larger genetics community, and we look forward to working together to learn from past examples, meet present challenges and support future opportunities.

    Nature Genetics 52, 135
  • News and Views |

    Despite the previous identification of genes involved in the treatment response to TNF inhibition in rheumatoid arthritis, no genetic biomarkers are currently used in clinical decision-making. Might the heterogeneous nature of the disease activity score, which is often used as the outcome measure in genetic studies, partly explain this gap?

    • Marieke J. H. Coenen
  • Comments and Opinion |

    In personalized medicine, a major aim is to provide the right treatment to the right patient. In this Comment article, Gibson discusses how a more overt and genomics-informed focus on those individuals who are unlikely to benefit from treatment could reduce prescription rates and provide financial and health-care benefits.

    • Greg Gibson
  • Editorial |

    Genomic research, sensitively deployed, has enormous potential to improve human health, animal health and agricultural crop quality and to guide sustainable contributions to the health of our environment. Within this broad context, we can learn from the metabolic adaptations and vulnerabilities of species threatened by environmental challenges in the context of climate change.

    Nature Genetics 50, 1061