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Pharmacodynamics (PD) is an area of pharmacology concerned with the relationship between a drug’s concentration at the site of action and the resulting effect, and to measurement of that relationship within an individual or group. Factors influencing a drug’s pharmacodynamics include the concentration of drug target and the signalling pathways downstream.
The coumarin extract of peegee hydrangea reverses gut microbiome dysbiosis, therefore exerting a protective effect against experimental membranous nephritis in rats.
Long-acting GIPR agonists, individually or as part of GIPR–GLP-1R co-agonists, are shown to require GIPR signaling in inhibitory GABAergic neurons to decrease body weight and food intake in mice.
Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein the authors report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class pan-phosphodiesterase inhibitor ZSP1601 in NAFLD patients.
