Pexophagy is a type of macroautophagy that selectively degrades perioxisomes. Double-membraned autophagosomes enclose perioxisomes, and then fuse with lysosomes for degradation.

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    Selective autophagy pathways engage selective autophagy receptors (SARs) that identify and bind to cellular cargoes (proteins or organelles) destined for degradation. Recent yeast studies have provided insights into the regulation and mechanisms underlying SAR function. As these mechanisms are conserved from yeast to mammals, it is now possible to formulate general principles of how selectivity during autophagy is achieved.

    • Jean-Claude Farr√©
    •  & Suresh Subramani

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