Personalized medicine

Personalized medicine is a therapeutic approach involving the use of an individual’s genetic and epigenetic information to tailor drug therapy or preventive care.

Latest Research and Reviews

  • Research | | open

    Personalized approaches to diagnosis and treatment monitoring could improve the management of cystic fibrosis patients. Here the authors show that multiscale differential dynamic microscopy can assess changes in cilia beating dynamics and coordination in patient-derived airway epithelial cells, in response to different CFTR-modulating drugs, in a patient-specific manner.

    • M. Chioccioli
    • , L. Feriani
    • , J. Kotar
    • , P. E. Bratcher
    •  & P. Cicuta
  • Research | | open

    Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.

    • Mark J. P. Chaisson
    • , Ashley D. Sanders
    • , Xuefang Zhao
    • , Ankit Malhotra
    • , David Porubsky
    • , Tobias Rausch
    • , Eugene J. Gardner
    • , Oscar L. Rodriguez
    • , Li Guo
    • , Ryan L. Collins
    • , Xian Fan
    • , Jia Wen
    • , Robert E. Handsaker
    • , Susan Fairley
    • , Zev N. Kronenberg
    • , Xiangmeng Kong
    • , Fereydoun Hormozdiari
    • , Dillon Lee
    • , Aaron M. Wenger
    • , Alex R. Hastie
    • , Danny Antaki
    • , Thomas Anantharaman
    • , Peter A. Audano
    • , Harrison Brand
    • , Stuart Cantsilieris
    • , Han Cao
    • , Eliza Cerveira
    • , Chong Chen
    • , Xintong Chen
    • , Chen-Shan Chin
    • , Zechen Chong
    • , Nelson T. Chuang
    • , Christine C. Lambert
    • , Deanna M. Church
    • , Laura Clarke
    • , Andrew Farrell
    • , Joey Flores
    • , Timur Galeev
    • , David U. Gorkin
    • , Madhusudan Gujral
    • , Victor Guryev
    • , William Haynes Heaton
    • , Jonas Korlach
    • , Sushant Kumar
    • , Jee Young Kwon
    • , Ernest T. Lam
    • , Jong Eun Lee
    • , Joyce Lee
    • , Wan-Ping Lee
    • , Sau Peng Lee
    • , Shantao Li
    • , Patrick Marks
    • , Karine Viaud-Martinez
    • , Sascha Meiers
    • , Katherine M. Munson
    • , Fabio C. P. Navarro
    • , Bradley J. Nelson
    • , Conor Nodzak
    • , Amina Noor
    • , Sofia Kyriazopoulou-Panagiotopoulou
    • , Andy W. C. Pang
    • , Yunjiang Qiu
    • , Gabriel Rosanio
    • , Mallory Ryan
    • , Adrian Stütz
    • , Diana C. J. Spierings
    • , Alistair Ward
    • , AnneMarie E. Welch
    • , Ming Xiao
    • , Wei Xu
    • , Chengsheng Zhang
    • , Qihui Zhu
    • , Xiangqun Zheng-Bradley
    • , Ernesto Lowy
    • , Sergei Yakneen
    • , Steven McCarroll
    • , Goo Jun
    • , Li Ding
    • , Chong Lek Koh
    • , Bing Ren
    • , Paul Flicek
    • , Ken Chen
    • , Mark B. Gerstein
    • , Pui-Yan Kwok
    • , Peter M. Lansdorp
    • , Gabor T. Marth
    • , Jonathan Sebat
    • , Xinghua Shi
    • , Ali Bashir
    • , Kai Ye
    • , Scott E. Devine
    • , Michael E. Talkowski
    • , Ryan E. Mills
    • , Tobias Marschall
    • , Jan O. Korbel
    • , Evan E. Eichler
    •  & Charles Lee
  • Reviews |

    Personalized multiple sclerosis therapy depends on evidence-based prognostication, an initial treatment choice and evaluation of early treatment responses to identify the need to switch therapy. In this Review, Rotstein and Montalban discuss the factors that need to be taken into account to make personalized treatment decisions.

    • Dalia Rotstein
    •  & Xavier Montalban
  • Research |

    A new standard allows the accuracy of variant calls to be assessed and compared across different technologies, variant types and genomic regions.

    • Peter Krusche
    • , Len Trigg
    • , Paul C. Boutros
    • , Christopher E. Mason
    • , Francisco M. De La Vega
    • , Benjamin L. Moore
    • , Mar Gonzalez-Porta
    • , Michael A. Eberle
    • , Zivana Tezak
    • , Samir Lababidi
    • , Rebecca Truty
    • , George Asimenos
    • , Birgit Funke
    • , Mark Fleharty
    • , Brad A. Chapman
    • , Marc Salit
    •  & Justin M. Zook

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