Peritoneal macrophages articles from across Nature Portfolio

GLPMs represent a population of fetal liver derived large peritoneal cavity Gata6+ macrophages, with the capacity to invade the tissues they surround. Here, in experimental colon cancer liver metastasis models, the authors show that GLPMs invade liver metastasis directly from the peritoneum, promoting liver metastases growth.

Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tissue.

Peritoneal adhesions are a major cause of complications after abdominal surgery. Here the authors use a post-operative abdominal adhesion model in mice to show that resident F4/80^HighCD206⁻ macrophages form a protective barrier that can be enhanced by IL-4 administration or adoptive transfer of these cells.

Differences in peritoneal macrophages between male and female mice depend on both their rate of renewal from the bone marrow and the influence of local tissue factors.

The transcription factor Bhlhe40 is required for the homeostatic proliferation of peritoneal macrophages and their expansion during type 2 immunity.

Monocytes recruited to the peritoneum under conditions of a type 2 inflammatory reaction can convert into resident-type macrophages under the control of vitamin A.