Peptides articles within Nature

Featured

  • Letter |

    This approach introduces an aryl substituent to the α-carbon of amino acids without a transition-metal catalyst, and uses the inherent chirality of the amino acid itself as the source of asymmetry.

    • Daniel J. Leonard
    • , John W. Ward
    •  & Jonathan Clayden

  • Article |

    Computational methods for the de novo design of conformationally restricted peptides produce exceptionally stable short peptides stabilized by backbone cyclization and/or internal disulfide bonds that are promising starting points for a new generation of peptide-based drugs.

    • Gaurav Bhardwaj
    • , Vikram Khipple Mulligan
    •  & David Baker

  • Article |

    The nasal commensal bacterium Staphylococcus lugdunensis produces a novel cyclic peptide antibiotic, lugdunin, that inhibits colonization by S. aureus in animal models and is associated with a significantly reduced S. aureus carriage rate in humans, suggesting that human commensal bacteria could be a valuable resource for the discovery of new antibiotics.

    • Alexander Zipperer
    • , Martin C. Konnerth
    •  & Bernhard Krismer

  • Article |

    The backbones of all natural peptides and proteins are composed of amide bonds. In the laboratory, the construction of such bonds generally relies on dehydrative approaches, although there are alternatives. It is now shown that the activation of amines and nitroalkanes with an electrophilic iodine source can lead directly to amide products.

    • Bo Shen
    • , Dawn M. Makley
    •  & Jeffrey N. Johnston

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