Peptide delivery

Peptide delivery is a method by which peptides are delivered into cells. Peptides could be used as drugs, for example to treat bacterial infections. Nanoparticles — particles of 1-100nm in size — and specially designed polymers have been used to deliver peptides into cells.

Latest Research and Reviews

News and Comment

  • News & Views |

    The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.

    • Pedro Romero
    • , Alena Donda
    •  & Jeffrey A. Hubbell
  • News & Views |

    An amphipathic peptide has been engineered and is capable of penetrating the blood–brain barrier as well as possessing a potent antiviral activity against Zika and other mosquito-borne viruses.

    • Jing Zou
    •  & Pei-Yong Shi
    Nature Materials 17, 955-956
  • News & Views |

    A study demonstrates that controlled integrin binding on a biomaterial was capable of promoting vascular cell sprouting and formation of a non-leaky blood vessel network in a healthy and diseased state.

    • Michael R. Blatchley
    •  & Sharon Gerecht
    Nature Materials 16, 881-883
  • News & Views |

    Intracellular protein delivery has been a major challenge in the field of cell biology for decades. Engineering such delivery is a key step in the development of protein- and antibody-based therapeutics. Now, two different approaches that enable the delivery of antibodies and antibody fragments into the cytosol have been developed.

    • Macarena Sánchez-Navarro
    • , Meritxell Teixidó
    •  & Ernest Giralt
    Nature Chemistry 9, 727-728