Peptide delivery articles within Nature Communications

Featured

• Article
  21 February 2024 | Open Access

  Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn

  Profiling antibody responses to vast antigenic spaces has been challenging using programmable phage display (PhIP-Seq). Here, authors develop a methodology for compressing large proteomic spaces and have discovered human antibodies targeting gut bacteria-infecting phages.

  • Anna-Maria Liebhoff
  • , Thiagarajan Venkataraman
  •  & H. Benjamin Larman

• Article
  04 January 2024 | Open Access

  A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

  The ongoing emergence of highly pathogenic viruses that evade immune-based therapies or lack interventions mandates new approaches, especially for on-demand prophylaxis. Here the authors provide a stapled lipopeptide platform for the rapid development of viral fusion inhibitors to combat outbreaks.

  • Gregory H. Bird
  • , J. J. Patten
  •  & Loren D. Walensky

• Article
  02 May 2023 | Open Access

  Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery

  Sustained drug delivery is critical for patient adherence to chronic disease treatments. Here the authors apply machine learning to engineer multifunctional peptides with high melanin binding, high cell-penetration, and low cytotoxicity, enhancing the duration and efficacy of peptide-drug conjugates for sustained ocular delivery.

  • Henry T. Hsueh
  • , Renee Ti Chou
  •  & Laura M. Ensign

• Article
  05 August 2022 | Open Access

  Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery

  Molecular chaperones play an important part in protein folding and delivery in nature. Here, the authors report on the creation of a synthetic chaperone to control the folding of therapeutic peptides from random coil to alpha helix and demonstrate enhanced therapeutic potential in an in vivo tumour model.

  • Il-Soo Park
  • , Seongchan Kim
  •  & Dal-Hee Min

• Article
  21 January 2022 | Open Access

  A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

  Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically. Here, the authors develop a Klotho-derived peptide, and show that it recapitulates the anti-fibrotic action of Klotho and prevents kidney fibrosis in mice by targeting TGF-β signalling.

  • Qian Yuan
  • , Qian Ren
  •  & Youhua Liu

• Article
  20 January 2022 | Open Access

  A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging

  Fluorescence probes for detecting tumours during surgery can suffer from poor accumulation and short imaging windows. Here, the author develop fluorescence probes with multiple motifs that permit enhanced circulation times, tumour targeting and use the probes to image pancreatic cancer in mice

  • Han Ren
  • , Xiang-Zhong Zeng
  •  & Li-Li Li

• Article
  18 October 2017 | Open Access

  Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

  The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.

  • Myriam M. Ouberai
  • , Ana L. Gomes Dos Santos
  •  & Mark E. Welland

• Article
  17 July 2017 | Open Access

  Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

  A major challenge for the application of peptide therapeutics is their short half-lifein vivo. Here, the authors design peptide-fatty acid chimeras bearing an engineered linker that promotes albumin binding and allows longer circulation times of therapeutic peptides in animal models.

  • Alessandro Zorzi
  • , Simon J. Middendorp
  •  & Christian Heinis

• Article
  06 June 2017 | Open Access

  Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

  In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to identify cell-penetrating peptides that can cross the BBB.

  • Choi-Fong Cho
  • , Justin M. Wolfe
  •  & Sean E. Lawler

• Article
  17 January 2017 | Open Access

  High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

  Assessing nanomaterials at the single cell level has proven to be complicated due to the limitations of existing techniques. Here, the authors utilised single-cell mass cytometry by time-of-flight as a label-free technique to analyse nanoparticle distribution within cells.

  • Yu-Sang Sabrina Yang
  • , Prabhani U. Atukorale
  •  & Darrell J. Irvine