Pattern recognition receptors

Pattern recognition receptors (PRRs) are expressed by cells in the body in order to sense molecules that are associated with infection or tissue damage. They are important for activating the immune system.

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Latest Research and Reviews

News and Comment

  • News & Views |

    The transition of Sub-Saharan Africans from rural settings and traditional plant-rich diets to urban settings and calorie-dense Westernized diets has led to specific shifts in serum metabolites and activates a heightened proinflammatory state in immune cells.

    • Robert T. Patry
    •  & Cathryn R. Nagler
    Nature Immunology 22, 266-268
  • Research Highlights |

    Two preprints describe a role for the RNA editor ADAR1 in recognizing Z-RNA to prevent spontaneous activation of the type I interferon pathway.

    • Ester Gea-Mallorquí
    •  & Sarah Rowland-Jones
  • News & Views |

    Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

    • Shouya Feng
    •  & Si Ming Man
    Nature Immunology 21, 829-830
  • Comments & Opinion |

    Takashi Fujita’s discovery of RNA helicases as intracellular viral replication sensors illustrates how scientific knowledge develops in logical — and sometimes illogical — ways.

    • Takashi Fujita
    Nature Immunology 21, 706-707
  • News & Views |

    Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

    • Florian I. Schmidt
    •  & Eicke Latz
    Nature Immunology 21, 718-719
  • News & Views |

    The identification of the acute phase protein serum amyloid A as a soluble allergen sensor sheds new light on the mechanisms involved in the induction of type II airway inflammation.

    • Rudi W. Hendriks
    Nature Immunology 21, 724-726