Pathogens are infectious agents, such as a bacterium, virus, fungus or parasite, that cause disease when they colonize a host organism.

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News and Comment

  • News & Views |

    Multi-drug resistant Mycobacterium abscessus clones from individuals who smoke have infiltrated the narrow niche of patients with cystic fibrosis, which has resulted in surprising specialization and subsequent worldwide dissemination.

    • Thierry Wirth
    Nature Microbiology 6, 1215-1216
  • News & Views |

    Some gut bacterial pathogens can escape antibody-mediated immunity by changing surface-exposed antigens, such as O-antigens. But by using vaccines targeting specific O-antigens to induce immunoglobulin A responses in the gut, such pathogens can also be directed to evolve towards expressing O-antigen variants that impair gut colonization.

    • Reiko Shinkura
    Nature Microbiology 6, 826-827
  • Comments & Opinion
    | Open Access

    Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.

    • Deyanira Pérez-Morales
    •  & Víctor H. Bustamante