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Next-generation sequencing has the potential to support public health surveillance systems to improve the early detection of emerging infectious diseases. This Review delineates the role of genomics in rapid outbreak response and the challenges that need to be tackled for genomics-informed pathogen surveillance to become a global reality.
The microbiota promotes resistance to respiratory infection through unclear mechanisms. Here, the authors identify members of the gut and upper airway microbiota that protect against respiratory infection by Streptococcus pneumoniae and Klebsiella pneumoniae by activating GM-CSF signaling.
A recent study revealed how H. pylori opens cell-to-cell junctions and traverses the gastric epithelium to bind to basolateral integrins, thereby activating the assembly and function of its type IV secretion system.
A recent study by Silvester et al. found that a conserved quorum sensing signalling pathway regulates interspecies crosstalk in trypanosome co-infections and provided novel insights into trypanosome virulence and transmission.
Increasingly, the pathogens that pose the greatest threats to humans are those that evolve to escape prior immunity and pharmaceutical interventions. In response, we need to employ evolutionary thinking to manage infectious disease.
This study found a new role for chaperone–usher pathway (CUP) pili in the colonization of the gut by uropathogenic Escherichia coli (UPEC) and identified a mannoside compound that could be used to prevent their binding to host cells.