Pathogenesis

Definition

Pathogenesis is the term that is used to describe the origin and development of a disease.

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Latest Research and Reviews

  • Reviews |

    Type 2 diabetes mellitus and obesity are major public health challenges; emerging evidence suggests that melatonin is involved in the development of these disorders, opening new avenues for research. This Review discusses the effect of melatonin and its receptors on glucose homeostasis, obesity and type 2 diabetes mellitus.

    • Angeliki Karamitri
    •  & Ralf Jockers
  • Research | | open

    Antigen present and presented in the structures of the skin can result in immune responses that elicit tolerance, protective immunity or allergy, depending on the immunological context. Here the authors describe a key role for the hair follicle and CD11b+ dendritic cells in the priming of local antigenic tolerance.

    • Leticia Tordesillas
    • , Daniel Lozano-Ojalvo
    • , David Dunkin
    • , Lucie Mondoulet
    • , Judith Agudo
    • , Miriam Merad
    • , Hugh A. Sampson
    •  & M. Cecilia Berin
  • Research | | open

    The antibody response during infection with dengue virus is a key component involved in the pathogenesis during secondary infection. Here the authors show antibodies targeting NS1 and the epitopes targeted can be associated with disease severity during human infection.

    • Deshni Jayathilaka
    • , Laksiri Gomes
    • , Chandima Jeewandara
    • , Geethal. S. Bandara Jayarathna
    • , Dhanushka Herath
    • , Pathum Asela Perera
    • , Samitha Fernando
    • , Ananda Wijewickrama
    • , Clare S. Hardman
    • , Graham S. Ogg
    •  & Gathsaurie Neelika Malavige
  • Research | | open

    Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation.

    • Sulayman Benmerzoug
    • , Stéphanie Rose
    • , Badreddine Bounab
    • , David Gosset
    • , Laure Duneau
    • , Pauline Chenuet
    • , Lucile Mollet
    • , Marc Le Bert
    • , Christopher Lambers
    • , Silvana Geleff
    • , Michael Roth
    • , Louis Fauconnier
    • , Delphine Sedda
    • , Clarisse Carvalho
    • , Olivier Perche
    • , David Laurenceau
    • , Bernhard Ryffel
    • , Lionel Apetoh
    • , Ahmet Kiziltunc
    • , Hakan Uslu
    • , Fadime Sultan Albez
    • , Metin Akgun
    • , Dieudonnée Togbe
    •  & Valerie F. J. Quesniaux

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