Pathogenesis

Pathogenesis is the term that is used to describe the origin and development of a disease.

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Latest Research and Reviews

  • Research |

    A systematic analysis of the proteostasis network of secreted proteins in Caenorhabditis elegans identifies numerous regulators of protein homeostasis outside the cell, and highlights the contribution of extracellular proteostasis to host defence.

    • Ivan Gallotta
    • , Aneet Sandhu
    • , Maximilian Peters
    • , Martin Haslbeck
    • , Raimund Jung
    • , Sinem Agilkaya
    • , Jane L. Blersch
    • , Christian Rödelsperger
    • , Waltraud Röseler
    • , Chaolie Huang
    • , Ralf J. Sommer
    •  & Della C. David
    Nature, 1-5
  • Research |

    An interbacterial toxin that catalyses the deamination of cytidines within double-stranded DNA forms part of a CRISPR-free, RNA-free base editing system that enables manipulation of human mitochondrial DNA.

    • Beverly Y. Mok
    • , Marcos H. de Moraes
    • , Jun Zeng
    • , Dustin E. Bosch
    • , Anna V. Kotrys
    • , Aditya Raguram
    • , FoSheng Hsu
    • , Matthew C. Radey
    • , S. Brook Peterson
    • , Vamsi K. Mootha
    • , Joseph D. Mougous
    •  & David R. Liu
    Nature, 1-7
  • Reviews |

    Purinergic signalling in the kidney maintains homeostasis and mediates injury-induced inflammation. The extracellular conversion of ATP into adenosine is critical for modulating these processes. Here, the authors discuss the pathological conditions associated with extracellular ATP metabolism and novel strategies for their treatment.

    • Karen M. Dwyer
    • , Bellamkonda K. Kishore
    •  & Simon C. Robson
  • Research
    | Open Access

    Benitez et al. show that mice lacking the autoimmune regulator Aire, which is important for T cell central tolerance, show an improved anti-tumor response and expansion of T cell clones with high tumor reactivity after anti-PD1 antibody treatment compared to wild-type mice. This study suggests a path towards improved immunotherapy strategies.

    • Asiel A. Benitez
    • , Sara Khalil-Agüero
    • , Anjali Nandakumar
    • , Namita T. Gupta
    • , Wen Zhang
    • , Gurinder S. Atwal
    • , Andrew J. Murphy
    • , Matthew A. Sleeman
    •  & Sokol Haxhinasto

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