Pathogenesis

  • Article | | open

    SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.

    • Lara M. Myers
    • , Michal Caspi Tal
    • , Laughing Bear Torrez Dulgeroff
    • , Aaron B. Carmody
    • , Ronald J. Messer
    • , Gunsagar Gulati
    • , Ying Ying Yiu
    • , Matthew M. Staron
    • , Cesar Lopez Angel
    • , Rahul Sinha
    • , Maxim Markovic
    • , Edward A. Pham
    • , Benjamin Fram
    • , Aijaz Ahmed
    • , Aaron M. Newman
    • , Jeffrey S. Glenn
    • , Mark M. Davis
    • , Susan M. Kaech
    • , Irving L. Weissman
    •  & Kim J. Hasenkrug
  • Article | | open

    FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.

    • María Cristina Estañ
    • , Elisa Fernández-Núñez
    • , Maha S. Zaki
    • , María Isabel Esteban
    • , Sandra Donkervoort
    • , Cynthia Hawkins
    • , José A. Caparros-Martin
    • , Dimah Saade
    • , Ying Hu
    • , Véronique Bolduc
    • , Katherine Ru-Yui Chao
    • , Julián Nevado
    • , Ana Lamuedra
    • , Raquel Largo
    • , Gabriel Herrero-Beaumont
    • , Javier Regadera
    • , Concepción Hernandez-Chico
    • , Eduardo F. Tizzano
    • , Victor Martinez-Glez
    • , Jaime J. Carvajal
    • , Ruiting Zong
    • , David L. Nelson
    • , Ghada A. Otaify
    • , Samia Temtamy
    • , Mona Aglan
    • , Mahmoud Issa
    • , Carsten G. Bönnemann
    • , Pablo Lapunzina
    • , Grace Yoon
    •  & Victor L. Ruiz-Perez
  • Article | | open

    Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.

    • Maik Luu
    • , Sabine Pautz
    • , Vanessa Kohl
    • , Rajeev Singh
    • , Rossana Romero
    • , Sébastien Lucas
    • , Jörg Hofmann
    • , Hartmann Raifer
    • , Niyati Vachharajani
    • , Lucia Campos Carrascosa
    • , Boris Lamp
    • , Andrea Nist
    • , Thorsten Stiewe
    • , Yoav Shaul
    • , Till Adhikary
    • , Mario M. Zaiss
    • , Matthias Lauth
    • , Ulrich Steinhoff
    •  & Alexander Visekruna
  • Article | | open

    Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.

    • Lin Wang
    • , Yilong Zhou
    • , Zijuan Chen
    • , Lei Sun
    • , Juehui Wu
    • , Haohao Li
    • , Feng Liu
    • , Fei Wang
    • , Chunfu Yang
    • , Juhao Yang
    • , Qibin Leng
    • , Qingli Zhang
    • , Ajing Xu
    • , Lisong Shen
    • , Jinqiao Sun
    • , Dianqing Wu
    • , Caiyun Fang
    • , Haojie Lu
    • , Dapeng Yan
    •  & Baoxue Ge
  • Article | | open

    Valyl-tRNA synthetase (VARS) charges valyl-tRNA with the amino acid valine, required for translation. Here, the authors describe a progressive epileptic encephalopathy in individuals from five families carrying biallelic mutations in the VARS gene that leave the enzyme activity partially intact.

    • Jennifer Friedman
    • , Desiree E. Smith
    • , Mahmoud Y. Issa
    • , Valentina Stanley
    • , Rengang Wang
    • , Marisa I. Mendes
    • , Meredith S. Wright
    • , Kristen Wigby
    • , Amber Hildreth
    • , John R. Crawford
    • , Alanna E. Koehler
    • , Shimul Chowdhury
    • , Shareef Nahas
    • , Liting Zhai
    • , Zhiwen Xu
    • , Wing-Sze Lo
    • , Kiely N. James
    • , Damir Musaev
    • , Andrea Accogli
    • , Kether Guerrero
    • , Luan T. Tran
    • , Tarek E. I. Omar
    • , Tawfeg Ben-Omran
    • , David Dimmock
    • , Stephen F. Kingsmore
    • , Gajja S. Salomons
    • , Maha S. Zaki
    • , Geneviève Bernard
    •  & Joseph G. Gleeson
  • Article | | open

    Type-2 innate lymphoid cells (ILC2s) are an immune population secreting Th2 cytokines playing a role in the regulation of adipose metabolic homeostasis. Here the authors show that engagement of GITR, a member of the TNF superfamily, in activated ILC2s is protective against insulin resistance in both a preventive and a therapeutic manner in the context of obesity.

    • Lauriane Galle-Treger
    • , Ishwarya Sankaranarayanan
    • , Benjamin P. Hurrell
    • , Emily Howard
    • , Richard Lo
    • , Hadi Maazi
    • , Gavin Lewis
    • , Homayon Banie
    • , Alan L. Epstein
    • , Peisheng Hu
    • , Virender K. Rehan
    • , Frank D. Gilliland
    • , Hooman Allayee
    • , Pejman Soroosh
    • , Arlene H. Sharpe
    •  & Omid Akbari
  • Article | | open

    tRNAs are linked with their cognate amino acid by aminoacyl tRNA synthetases (ARS). Here, the authors report a developmental encephalopathy associated with biallelic VARS variants (valyl-tRNA synthetase) that lead to loss of function, as determined by several in vitro assays and a vars knockout zebrafish model.

    • Aleksandra Siekierska
    • , Hannah Stamberger
    • , Tine Deconinck
    • , Stephanie N. Oprescu
    • , Michèle Partoens
    • , Yifan Zhang
    • , Jo Sourbron
    • , Elias Adriaenssens
    • , Patrick Mullen
    • , Patrick Wiencek
    • , Katia Hardies
    • , Jeong-Soo Lee
    • , Hoi-Khoanh Giong
    • , Felix Distelmaier
    • , Orly Elpeleg
    • , Katherine L. Helbig
    • , Joseph Hersh
    • , Sedat Isikay
    • , Elizabeth Jordan
    • , Ender Karaca
    • , Angela Kecskes
    • , James R. Lupski
    • , Reka Kovacs-Nagy
    • , Patrick May
    • , Vinodh Narayanan
    • , Manuela Pendziwiat
    • , Keri Ramsey
    • , Sampathkumar Rangasamy
    • , Deepali N. Shinde
    • , Ronen Spiegel
    • , Vincent Timmerman
    • , Sarah von Spiczak
    • , Ingo Helbig
    • , Chris Balak
    • , Newell Belnap
    • , Ana Claasen
    • , Amanda Courtright
    • , Matt de Both
    • , Matthew J. Huentelman
    • , Marcus Naymik
    • , Ryan Richholt
    • , Ashley L. Siniard
    • , Szabolcs Szelinger
    • , David W. Craig
    • , Isabelle Schrauwen
    • , Zaid Afawi
    • , Rudi Balling
    • , Stéphanie Baulac
    • , Nina Barišić
    • , Hande S. Caglayan
    • , Dana Craiu
    • , Rosa Guerrero-López
    • , Renzo Guerrini
    • , Helle Hjalgrim
    • , Johanna Jähn
    • , Karl Martin Klein
    • , Eric Leguern
    • , Johannes R. Lemke
    • , Holger Lerche
    • , Carla Marini
    • , Rikke S. Møller
    • , Hiltrud Muhle
    • , Felix Rosenow
    • , Jose Serratosa
    • , Arvid Suls
    • , Ulrich Stephani
    • , Katalin Štěrbová
    • , Pasquale Striano
    • , Federico Zara
    • , Sarah Weckhuysen
    • , Christopher Francklyn
    • , Anthony Antonellis
    • , Peter de Witte
    •  & Peter De Jonghe
  • Article | | open

    T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmunity.

    • Hong-Gyun Lee
    • , Jae-Ung Lee
    • , Do-Hyun Kim
    • , Sangho Lim
    • , Insoo Kang
    •  & Je-Min Choi
  • Article | | open

    Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.

    • Jessica Gräb
    • , Isabelle Suárez
    • , Edeltraud van Gumpel
    • , Sandra Winter
    • , Fynn Schreiber
    • , Anna Esser
    • , Christoph Hölscher
    • , Melanie Fritsch
    • , Marc Herb
    • , Michael Schramm
    • , Laurens Wachsmuth
    • , Christian Pallasch
    • , Manolis Pasparakis
    • , Hamid Kashkar
    •  & Jan Rybniker
  • Article | | open

    Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.

    • Rory Henderson
    • , Brian E. Watts
    • , Hieu N. Ergin
    • , Kara Anasti
    • , Robert Parks
    • , Shi-Mao Xia
    • , Ashley Trama
    • , Hua-Xin Liao
    • , Kevin O. Saunders
    • , Mattia Bonsignori
    • , Kevin Wiehe
    • , Barton F. Haynes
    •  & S. Munir Alam
  • Article | | open

    High-throughput sequencing and analyzes of antibody repertoire provide important information on immune responses, but current methodologies are limited in sequence assembly precision and haplotype inference validity. Here the authors propose a new Bayesian haplotyping method, and attest its broad application with a large, multi-individual dataset.

    • Moriah Gidoni
    • , Omri Snir
    • , Ayelet Peres
    • , Pazit Polak
    • , Ida Lindeman
    • , Ivana Mikocziova
    • , Vikas Kumar Sarna
    • , Knut E. A. Lundin
    • , Christopher Clouser
    • , Francois Vigneault
    • , Andrew M. Collins
    • , Ludvig M. Sollid
    •  & Gur Yaari
  • Article | | open

    Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance molecule A signalling.

    • Andreas Körner
    • , Martin Schlegel
    • , Torsten Kaussen
    • , Verena Gudernatsch
    • , Georg Hansmann
    • , Timo Schumacher
    • , Martin Giera
    •  & Valbona Mirakaj
  • Article | | open

    Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance without clear adverse effects or the need for chronic immune suppression.

    • Zhanzhuo Li
    • , Agnieszka Czechowicz
    • , Amelia Scheck
    • , Derrick J. Rossi
    •  & Philip M. Murphy
  • Article | | open

    Host genetics modulates gut microbiota composition, which in turn affects host health, but little is known about the specific genes involved. Here, Berg et al. show that TGFβ/BMP immune signalling affects abundance and function of commensal Enterobacter species in C. elegans.

    • Maureen Berg
    • , David Monnin
    • , Juhyun Cho
    • , Lydia Nelson
    • , Alex Crits-Christoph
    •  & Michael Shapira
  • Article | | open

    Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.

    • Linda Reiling
    • , Michelle J. Boyle
    • , Michael T. White
    • , Danny W. Wilson
    • , Gaoqian Feng
    • , Rupert Weaver
    • , D. Herbert Opi
    • , Kristina E. M. Persson
    • , Jack S. Richards
    • , Peter M. Siba
    • , Freya J. I. Fowkes
    • , Eizo Takashima
    • , Takafumi Tsuboi
    • , Ivo Mueller
    •  & James G. Beeson
  • Article | | open

    Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability is driven by cyclin D1 deficiency induced by SMARCA4 loss.

    • Yibo Xue
    • , Brian Meehan
    • , Elizabeth Macdonald
    • , Sriram Venneti
    • , Xue Qing D. Wang
    • , Leora Witkowski
    • , Petar Jelinic
    • , Tim Kong
    • , Daniel Martinez
    • , Geneviève Morin
    • , Michelle Firlit
    • , Atefeh Abedini
    • , Radia M. Johnson
    • , Regina Cencic
    • , Jay Patibandla
    • , Hongbo Chen
    • , Andreas I. Papadakis
    • , Aurelie Auguste
    • , Iris de Rink
    • , Ron M. Kerkhoven
    • , Nicholas Bertos
    • , Walter H. Gotlieb
    • , Blaise A. Clarke
    • , Alexandra Leary
    • , Michael Witcher
    • , Marie-Christine Guiot
    • , Jerry Pelletier
    • , Josée Dostie
    • , Morag Park
    • , Alexander R. Judkins
    • , Ralf Hass
    • , Douglas A. Levine
    • , Janusz Rak
    • , Barbara Vanderhyden
    • , William D. Foulkes
    •  & Sidong Huang
  • Article | | open

    A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by directly activating Bhlhe40 and modulating PD-1.

    • Keiko Yasuda
    • , Yohko Kitagawa
    • , Ryoji Kawakami
    • , Yoshitaka Isaka
    • , Hitomi Watanabe
    • , Gen Kondoh
    • , Terumi Kohwi-Shigematsu
    • , Shimon Sakaguchi
    •  & Keiji Hirota
  • Article | | open

    Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca2+ flux upon target recognition and NK cell activation.

    • Jodie P. Goodridge
    • , Benedikt Jacobs
    • , Michelle L. Saetersmoen
    • , Dennis Clement
    • , Quirin Hammer
    • , Trevor Clancy
    • , Ellen Skarpen
    • , Andreas Brech
    • , Johannes Landskron
    • , Christian Grimm
    • , Aline Pfefferle
    • , Leonardo Meza-Zepeda
    • , Susanne Lorenz
    • , Merete Thune Wiiger
    • , William E. Louch
    • , Eivind Heggernes Ask
    • , Lisa L. Liu
    • , Vincent Yi Sheng Oei
    • , Una Kjällquist
    • , Sten Linnarsson
    • , Sandip Patel
    • , Kjetil Taskén
    • , Harald Stenmark
    •  & Karl-Johan Malmberg
  • Article | | open

    Adeno-associated viral vectors (AAV) are being developed for gene therapy of skeletal muscle, but it is a challenge to achieve robust gene expression. Here, the authors identify muscle-specific cisregulatory elements that lead to a substantial increase in micro-dystrophin and follistatin expression, resulting in a safe and sustainable rescue of the dystrophic phenotype in mouse models.

    • S. Sarcar
    • , W. Tulalamba
    • , M. Y. Rincon
    • , J. Tipanee
    • , H. Q. Pham
    • , H. Evens
    • , D. Boon
    • , E. Samara-Kuko
    • , M. Keyaerts
    • , M. Loperfido
    • , E. Berardi
    • , S. Jarmin
    • , P. In’t Veld
    • , G. Dickson
    • , T. Lahoutte
    • , M. Sampaolesi
    • , P. De Bleser
    • , T. VandenDriessche
    •  & M. K. Chuah
  • Article | | open

    The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.

    • Vivek Bhaskaran
    • , Michal O. Nowicki
    • , Mahmoud Idriss
    • , Miguel A. Jimenez
    • , Gianmarco Lugli
    • , Josie L. Hayes
    • , Ahmad Bakur Mahmoud
    • , Rachel E. Zane
    • , Carmela Passaro
    • , Keith L. Ligon
    • , Daphne Haas-Kogan
    • , Agnieszka Bronisz
    • , Jakub Godlewski
    • , Sean E. Lawler
    • , E. Antonio Chiocca
    •  & Pierpaolo Peruzzi
  • Article | | open

    Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady state, help promote ILC2 activation and type 2 cytokine production in lung allergy mouse models.

    • Chizuko Miyamoto
    • , Satoshi Kojo
    • , Motoi Yamashita
    • , Kazuyo Moro
    • , Georges Lacaud
    • , Katsuyuki Shiroguchi
    • , Ichiro Taniuchi
    •  & Takashi Ebihara
  • Article | | open

    Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

    • Xia Jiang
    • , Hilary K. Finucane
    • , Fredrick R. Schumacher
    • , Stephanie L. Schmit
    • , Jonathan P. Tyrer
    • , Younghun Han
    • , Kyriaki Michailidou
    • , Corina Lesseur
    • , Karoline B. Kuchenbaecker
    • , Joe Dennis
    • , David V. Conti
    • , Graham Casey
    • , Mia M. Gaudet
    • , Jeroen R. Huyghe
    • , Demetrius Albanes
    • , Melinda C. Aldrich
    • , Angeline S. Andrew
    • , Irene L. Andrulis
    • , Hoda Anton-Culver
    • , Antonis C. Antoniou
    • , Natalia N. Antonenkova
    • , Susanne M. Arnold
    • , Kristan J. Aronson
    • , Banu K. Arun
    • , Elisa V. Bandera
    • , Rosa B. Barkardottir
    • , Daniel R. Barnes
    • , Jyotsna Batra
    • , Matthias W. Beckmann
    • , Javier Benitez
    • , Sara Benlloch
    • , Andrew Berchuck
    • , Sonja I. Berndt
    • , Heike Bickeböller
    • , Stephanie A. Bien
    • , Carl Blomqvist
    • , Stefania Boccia
    • , Natalia V. Bogdanova
    • , Stig E. Bojesen
    • , Manjeet K. Bolla
    • , Hiltrud Brauch
    • , Hermann Brenner
    • , James D. Brenton
    • , Mark N. Brook
    • , Joan Brunet
    • , Hans Brunnström
    • , Daniel D. Buchanan
    • , Barbara Burwinkel
    • , Ralf Butzow
    • , Gabriella Cadoni
    • , Trinidad Caldés
    • , Maria A. Caligo
    • , Ian Campbell
    • , Peter T. Campbell
    • , Géraldine Cancel-Tassin
    • , Lisa Cannon-Albright
    • , Daniele Campa
    • , Neil Caporaso
    • , André L. Carvalho
    • , Andrew T. Chan
    • , Jenny Chang-Claude
    • , Stephen J. Chanock
    • , Chu Chen
    • , David C. Christiani
    • , Kathleen B. M. Claes
    • , Frank Claessens
    • , Judith Clements
    • , J. Margriet Collée
    • , Marcia Cruz Correa
    • , Fergus J. Couch
    • , Angela Cox
    • , Julie M. Cunningham
    • , Cezary Cybulski
    • , Kamila Czene
    • , Mary B. Daly
    • , Anna deFazio
    • , Peter Devilee
    • , Orland Diez
    • , Manuela Gago-Dominguez
    • , Jenny L. Donovan
    • , Thilo Dörk
    • , Eric J. Duell
    • , Alison M. Dunning
    • , Miriam Dwek
    • , Diana M. Eccles
    • , Christopher K. Edlund
    • , Digna R Velez Edwards
    • , Carolina Ellberg
    • , D. Gareth Evans
    • , Peter A. Fasching
    • , Robert L. Ferris
    • , Triantafillos Liloglou
    • , Jane C. Figueiredo
    • , Olivia Fletcher
    • , Renée T. Fortner
    • , Florentia Fostira
    • , Silvia Franceschi
    • , Eitan Friedman
    • , Steven J. Gallinger
    • , Patricia A. Ganz
    • , Judy Garber
    • , José A. García-Sáenz
    • , Simon A. Gayther
    • , Graham G. Giles
    • , Andrew K. Godwin
    • , Mark S. Goldberg
    • , David E. Goldgar
    • , Ellen L. Goode
    • , Marc T. Goodman
    • , Gary Goodman
    • , Kjell Grankvist
    • , Mark H. Greene
    • , Henrik Gronberg
    • , Jacek Gronwald
    • , Pascal Guénel
    • , Niclas Håkansson
    • , Per Hall
    • , Ute Hamann
    • , Freddie C. Hamdy
    • , Robert J. Hamilton
    • , Jochen Hampe
    • , Aage Haugen
    • , Florian Heitz
    • , Rolando Herrero
    • , Peter Hillemanns
    • , Michael Hoffmeister
    • , Estrid Høgdall
    • , Yun-Chul Hong
    • , John L. Hopper
    • , Richard Houlston
    • , Peter J. Hulick
    • , David J. Hunter
    • , David G. Huntsman
    • , Gregory Idos
    • , Evgeny N. Imyanitov
    • , Sue Ann Ingles
    • , Claudine Isaacs
    • , Anna Jakubowska
    • , Paul James
    • , Mark A. Jenkins
    • , Mattias Johansson
    • , Mikael Johansson
    • , Esther M. John
    • , Amit D. Joshi
    • , Radka Kaneva
    • , Beth Y. Karlan
    • , Linda E. Kelemen
    • , Tabea Kühl
    • , Kay-Tee Khaw
    • , Elza Khusnutdinova
    • , Adam S. Kibel
    • , Lambertus A. Kiemeney
    • , Jeri Kim
    • , Susanne K. Kjaer
    • , Julia A. Knight
    • , Manolis Kogevinas
    • , Zsofia Kote-Jarai
    • , Stella Koutros
    • , Vessela N. Kristensen
    • , Jolanta Kupryjanczyk
    • , Martin Lacko
    • , Stephan Lam
    • , Diether Lambrechts
    • , Maria Teresa Landi
    • , Philip Lazarus
    • , Nhu D. Le
    • , Eunjung Lee
    • , Flavio Lejbkowicz
    • , Heinz-Josef Lenz
    • , Goska Leslie
    • , Davor Lessel
    • , Jenny Lester
    • , Douglas A. Levine
    • , Li Li
    • , Christopher I. Li
    • , Annika Lindblom
    • , Noralane M. Lindor
    • , Geoffrey Liu
    • , Fotios Loupakis
    • , Jan Lubiński
    • , Lovise Maehle
    • , Christiane Maier
    • , Arto Mannermaa
    • , Loic Le Marchand
    • , Sara Margolin
    • , Taymaa May
    • , Lesley McGuffog
    • , Alfons Meindl
    • , Pooja Middha
    • , Austin Miller
    • , Roger L. Milne
    • , Robert J. MacInnis
    • , Francesmary Modugno
    • , Marco Montagna
    • , Victor Moreno
    • , Kirsten B. Moysich
    • , Lorelei Mucci
    • , Kenneth Muir
    • , Anna Marie Mulligan
    • , Katherine L. Nathanson
    • , David E. Neal
    • , Andrew R. Ness
    • , Susan L. Neuhausen
    • , Heli Nevanlinna
    • , Polly A. Newcomb
    • , Lisa F. Newcomb
    • , Finn Cilius Nielsen
    • , Liene Nikitina-Zake
    • , Børge G. Nordestgaard
    • , Robert L. Nussbaum
    • , Kenneth Offit
    • , Edith Olah
    • , Ali Amin Al Olama
    • , Olufunmilayo I. Olopade
    • , Andrew F. Olshan
    • , Håkan Olsson
    • , Ana Osorio
    • , Hardev Pandha
    • , Jong Y. Park
    • , Nora Pashayan
    • , Michael T. Parsons
    • , Tanja Pejovic
    • , Kathryn L. Penney
    • , Wilbert H M. Peters
    • , Catherine M. Phelan
    • , Amanda I. Phipps
    • , Dijana Plaseska-Karanfilska
    • , Miranda Pring
    • , Darya Prokofyeva
    • , Paolo Radice
    • , Kari Stefansson
    • , Susan J. Ramus
    • , Leon Raskin
    • , Gad Rennert
    • , Hedy S. Rennert
    • , Elizabeth J. van Rensburg
    • , Marjorie J. Riggan
    • , Harvey A. Risch
    • , Angela Risch
    • , Monique J. Roobol
    • , Barry S. Rosenstein
    • , Mary Anne Rossing
    • , Kim De Ruyck
    • , Emmanouil Saloustros
    • , Dale P. Sandler
    • , Elinor J. Sawyer
    • , Matthew B. Schabath
    • , Johanna Schleutker
    • , Marjanka K. Schmidt
    • , V. Wendy Setiawan
    • , Hongbing Shen
    • , Erin M. Siegel
    • , Weiva Sieh
    • , Christian F. Singer
    • , Martha L. Slattery
    • , Karina Dalsgaard Sorensen
    • , Melissa C. Southey
    • , Amanda B. Spurdle
    • , Janet L. Stanford
    • , Victoria L. Stevens
    • , Sebastian Stintzing
    • , Jennifer Stone
    • , Karin Sundfeldt
    • , Rebecca Sutphen
    • , Anthony J. Swerdlow
    • , Eloiza H. Tajara
    • , Catherine M. Tangen
    • , Adonina Tardon
    • , Jack A. Taylor
    • , M. Dawn Teare
    • , Manuel R. Teixeira
    • , Mary Beth Terry
    • , Kathryn L. Terry
    • , Stephen N. Thibodeau
    • , Mads Thomassen
    • , Line Bjørge
    • , Marc Tischkowitz
    • , Amanda E. Toland
    • , Diana Torres
    • , Paul A. Townsend
    • , Ruth C. Travis
    • , Nadine Tung
    • , Shelley S. Tworoger
    • , Cornelia M. Ulrich
    • , Nawaid Usmani
    • , Celine M. Vachon
    • , Els Van Nieuwenhuysen
    • , Ana Vega
    • , Miguel Elías Aguado-Barrera
    • , Qin Wang
    • , Penelope M. Webb
    • , Clarice R. Weinberg
    • , Stephanie Weinstein
    • , Mark C. Weissler
    • , Jeffrey N. Weitzel
    • , Catharine M. L. West
    • , Emily White
    • , Alice S. Whittemore
    • , H-Erich Wichmann
    • , Fredrik Wiklund
    • , Robert Winqvist
    • , Alicja Wolk
    • , Penella Woll
    • , Michael Woods
    • , Anna H. Wu
    • , Xifeng Wu
    • , Drakoulis Yannoukakos
    • , Wei Zheng
    • , Shanbeh Zienolddiny
    • , Argyrios Ziogas
    • , Kristin K. Zorn
    • , Jacqueline M. Lane
    • , Richa Saxena
    • , Duncan Thomas
    • , Rayjean J. Hung
    • , Brenda Diergaarde
    • , James McKay
    • , Ulrike Peters
    • , Li Hsu
    • , Montserrat García-Closas
    • , Rosalind A. Eeles
    • , Georgia Chenevix-Trench
    • , Paul J. Brennan
    • , Christopher A. Haiman
    • , Jacques Simard
    • , Douglas F. Easton
    • , Stephen B. Gruber
    • , Paul D. P. Pharoah
    • , Alkes L. Price
    • , Bogdan Pasaniuc
    • , Christopher I. Amos
    • , Peter Kraft
    •  & Sara Lindström
  • Article | | open

    GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.

    • Ying Jin
    • , Genevieve H. L. Roberts
    • , Tracey M. Ferrara
    • , Songtao Ben
    • , Nanja van Geel
    • , Albert Wolkerstorfer
    • , Khaled Ezzedine
    • , Janet Siebert
    • , Charles P. Neff
    • , Brent E. Palmer
    • , Stephanie A. Santorico
    •  & Richard A. Spritz
  • Article | | open

    Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.

    • Florian Haller
    • , Matthias Bieg
    • , Rainer Will
    • , Cindy Körner
    • , Dieter Weichenhan
    • , Alexander Bott
    • , Naveed Ishaque
    • , Pavlo Lutsik
    • , Evgeny A. Moskalev
    • , Sarina K. Mueller
    • , Marion Bähr
    • , Angelika Woerner
    • , Birgit Kaiser
    • , Claudia Scherl
    • , Marlen Haderlein
    • , Kortine Kleinheinz
    • , Rainer Fietkau
    • , Heinrich Iro
    • , Roland Eils
    • , Arndt Hartmann
    • , Christoph Plass
    • , Stefan Wiemann
    •  & Abbas Agaimy
  • Article | | open

    The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity.

    • Bing Liu
    • , Oscar C. Salgado
    • , Sangya Singh
    • , Keli L. Hippen
    • , Jason C. Maynard
    • , Alma L. Burlingame
    • , Lauren E. Ball
    • , Bruce R. Blazar
    • , Michael A. Farrar
    • , Kristin A. Hogquist
    •  & Hai-Bin Ruan
  • Article | | open

    There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.

    • Lei Xiong
    • , Feng Wu
    • , Qiong Wu
    • , Liangliang Xu
    • , Otto K. Cheung
    • , Wei Kang
    • , Myth T. Mok
    • , Lemuel L. M. Szeto
    • , Cheuk-Yin Lun
    • , Raymond W. Lung
    • , Jinglin Zhang
    • , Ken H. Yu
    • , Sau-Dan Lee
    • , Guangcun Huang
    • , Chiou-Miin Wang
    • , Joseph Liu
    • , Zhuo Yu
    • , Dae-Yeul Yu
    • , Jian-Liang Chou
    • , Wan-Hong Huang
    • , Bo Feng
    • , Yue-Sun Cheung
    • , Paul B. Lai
    • , Patrick Tan
    • , Nathalie Wong
    • , Michael W. Chan
    • , Tim H. Huang
    • , Kevin Y. Yip
    • , Alfred S. Cheng
    •  & Ka-Fai To
  • Article | | open

    Immune recognition of Influenza B virus (IBV) is poorly understood. Here, Liu et al. use flow cytometry to characterize IBV-specific memory B cell responses following seasonal vaccination and show that elicited cross-reactive antibodies can protect against infection, providing a platform for vaccine design.

    • Yi Liu
    • , Hyon-Xhi Tan
    • , Marios Koutsakos
    • , Sinthujan Jegaskanda
    • , Robyn Esterbauer
    • , Danielle Tilmanis
    • , Malet Aban
    • , Katherine Kedzierska
    • , Aeron C. Hurt
    • , Stephen J. Kent
    •  & Adam K. Wheatley
  • Article | | open

    Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulating both its enzymatic activity and RNA-binding capacity.

    • Silvia Galván-Peña
    • , Richard G. Carroll
    • , Carla Newman
    • , Elizabeth C. Hinchy
    • , Eva Palsson-McDermott
    • , Elektra K. Robinson
    • , Sergio Covarrubias
    • , Alan Nadin
    • , Andrew M. James
    • , Moritz Haneklaus
    • , Susan Carpenter
    • , Vincent P. Kelly
    • , Michael P. Murphy
    • , Louise K. Modis
    •  & Luke A. O’Neill
  • Article | | open

    Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.

    • Quanbo Ji
    • , Xiaojie Xu
    • , Lei Kang
    • , Yameng Xu
    • , Jingbo Xiao
    • , Stuart B. Goodman
    • , Xiang Zhu
    • , Wenchao Li
    • , Juan Liu
    • , Xu Gao
    • , Zhifeng Yan
    • , Yuxuan Zheng
    • , Zheng Wang
    • , William J. Maloney
    • , Qinong Ye
    •  & Yan Wang
  • Article | | open

    Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease.

    • Elizabeth A. Caine
    • , Suzanne M. Scheaffer
    • , Nitin Arora
    • , Konstantin Zaitsev
    • , Maxim N. Artyomov
    • , Carolyn B. Coyne
    • , Kelle H. Moley
    •  & Michael S. Diamond
  • Article | | open

    Long noncoding RNA (lncRNA) genes do not encode protein products yet are emerging as key regulators of cellular processes such as transcription and translation. Here, by examining lncRNA profiles from human and mouse CD8 T cells, the authors show that stages of CD8+ T cell differentiation are defined by expression of lncRNA genes.

    • William H. Hudson
    • , Nataliya Prokhnevska
    • , Julia Gensheimer
    • , Rama Akondy
    • , Donald J. McGuire
    • , Rafi Ahmed
    •  & Haydn T. Kissick
  • Article | | open

    B cells produce antibodies to mediate various immune functions, but are also reported to negatively regulate immune responses. Here, the authors show that a subset of mature B cells expressing low levels of IgD, present in both mice and human, may pursue this regulatory function indirectly by inducing the proliferation of regulatory T cells via GITRL.

    • Avijit Ray
    • , Mohamed I. Khalil
    • , Kirthi L. Pulakanti
    • , Robert T. Burns
    • , Cody J. Gurski
    • , Sreemanti Basu
    • , Demin Wang
    • , Sridhar Rao
    •  & Bonnie N. Dittel
  • Article | | open

    Targeting the immune-stimulatory receptor 4-1BB has only yielded modest benefit in cancer treatment. In this study, the authors show that CD73 expression on effector T cells sustained by TGF-β drives tumor resistance to anti-4-1BB therapy and therefore TGF- β blockade can be used to overcome such resistance.

    • Siqi Chen
    • , Jie Fan
    • , Minghui Zhang
    • , Lei Qin
    • , Donye Dominguez
    • , Alan Long
    • , Gaoxiang Wang
    • , Renqiang Ma
    • , Huabin Li
    • , Yi Zhang
    • , Deyu Fang
    • , Jeffrey Sosman
    •  & Bin Zhang
  • Article | | open

    Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.

    • Rajbir Singh
    • , Sandeep Chandrashekharappa
    • , Sobha R. Bodduluri
    • , Becca V. Baby
    • , Bindu Hegde
    • , Niranjan G. Kotla
    • , Ankita A. Hiwale
    • , Taslimarif Saiyed
    • , Paresh Patel
    • , Matam Vijay-Kumar
    • , Morgan G. I. Langille
    • , Gavin M. Douglas
    • , Xi Cheng
    • , Eric C. Rouchka
    • , Sabine J. Waigel
    • , Gerald W. Dryden
    • , Houda Alatassi
    • , Huang-Ge Zhang
    • , Bodduluri Haribabu
    • , Praveen K. Vemula
    •  & Venkatakrishna R. Jala
  • Article | | open

    The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides, and mild memory impairment that resolves with fungal clearance.

    • Yifan Wu
    • , Shuqi Du
    • , Jennifer L. Johnson
    • , Hui-Ying Tung
    • , Cameron T. Landers
    • , Yuwei Liu
    • , Brittany G. Seman
    • , Robert T. Wheeler
    • , Mauro Costa-Mattioli
    • , Farrah Kheradmand
    • , Hui Zheng
    •  & David B. Corry
  • Article | | open

    CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

    • Adam Shahine
    • , Peter Reinink
    • , Josephine F. Reijneveld
    • , Stephanie Gras
    • , Mira Holzheimer
    • , Tan-Yun Cheng
    • , Adriaan J. Minnaard
    • , John D. Altman
    • , Steffi Lenz
    • , Jacques Prandi
    • , Joanna Kubler-Kielb
    • , D. Branch Moody
    • , Jamie Rossjohn
    •  & Ildiko Van Rhijn
  • Article | | open

    The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.

    • Yael Haberman
    • , Rebekah Karns
    • , Phillip J. Dexheimer
    • , Melanie Schirmer
    • , Judith Somekh
    • , Ingrid Jurickova
    • , Tzipi Braun
    • , Elizabeth Novak
    • , Laura Bauman
    • , Margaret H. Collins
    • , Angela Mo
    • , Michael J. Rosen
    • , Erin Bonkowski
    • , Nathan Gotman
    • , Alison Marquis
    • , Mason Nistel
    • , Paul A. Rufo
    • , Susan S. Baker
    • , Cary G. Sauer
    • , James Markowitz
    • , Marian D. Pfefferkorn
    • , Joel R. Rosh
    • , Brendan M. Boyle
    • , David R. Mack
    • , Robert N. Baldassano
    • , Sapana Shah
    • , Neal S. Leleiko
    • , Melvin B. Heyman
    • , Anne M. Grifiths
    • , Ashish S. Patel
    • , Joshua D. Noe
    • , Bruce J. Aronow
    • , Subra Kugathasan
    • , Thomas D. Walters
    • , Greg Gibson
    • , Sonia Davis Thomas
    • , Kevin Mollen
    • , Shai Shen-Orr
    • , Curtis Huttenhower
    • , Ramnik J. Xavier
    • , Jeffrey S. Hyams
    •  & Lee A. Denson
  • Article | | open

    The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.

    • Koen Venken
    • , Peggy Jacques
    • , Céline Mortier
    • , Mark E. Labadia
    • , Tine Decruy
    • , Julie Coudenys
    • , Kathleen Hoyt
    • , Anita L. Wayne
    • , Robert Hughes
    • , Michael Turner
    • , Sofie Van Gassen
    • , Liesbet Martens
    • , Dustin Smith
    • , Christian Harcken
    • , Joseph Wahle
    • , Chao-Ting Wang
    • , Eveline Verheugen
    • , Nadia Schryvers
    • , Gaëlle Varkas
    • , Heleen Cypers
    • , Ruth Wittoek
    • , Yves Piette
    • , Lieve Gyselbrecht
    • , Serge Van Calenbergh
    • , Filip Van den Bosch
    • , Yvan Saeys
    • , Gerald Nabozny
    •  & Dirk Elewaut
  • Article | | open

    Transient aneuploidy enables cells to survive sudden environmental changes before longterm cellular adaptations are established. Here, the authors show that yeast cells respond to the acute loss of Ulp2 SUMO protease by rapid induction of aneuploidy, and reveal predictable long-term adaptation mechanisms that restore euploidy.

    • Hong-Yeoul Ryu
    • , Francesc López-Giráldez
    • , James Knight
    • , Soo Seok Hwang
    • , Christina Renner
    • , Stefan G. Kreft
    •  & Mark Hochstrasser
  • Article | | open

    Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact and cross reactivity of two human immunodominant influenza epitope variants.

    • Emma J. Grant
    • , Tracy M. Josephs
    • , Liyen Loh
    • , E. Bridie Clemens
    • , Sneha Sant
    • , Mandvi Bharadwaj
    • , Weisan Chen
    • , Jamie Rossjohn
    • , Stephanie Gras
    •  & Katherine Kedzierska
  • Article | | open

    Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.

    • Eileen McNeill
    • , Elena Stylianou
    • , Mark J. Crabtree
    • , Rachel Harrington-Kandt
    • , Anna-Lena Kolb
    • , Marina Diotallevi
    • , Ashley B. Hale
    • , Paulo Bettencourt
    • , Rachel Tanner
    • , Matthew K. O’Shea
    • , Magali Matsumiya
    • , Helen Lockstone
    • , Julius Müller
    • , Helen A. Fletcher
    • , David R. Greaves
    • , Helen McShane
    •  & Keith M. Channon
  • Article | | open

    SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.

    • Konstantinos Tzelepis
    • , Etienne De Braekeleer
    • , Demetrios Aspris
    • , Isaia Barbieri
    • , M. S. Vijayabaskar
    • , Wen-Hsin Liu
    • , Malgorzata Gozdecka
    • , Emmanouil Metzakopian
    • , Hamish D. Toop
    • , Monika Dudek
    • , Samuel C. Robson
    • , Francisco Hermida-Prado
    • , Yu Hsuen Yang
    • , Roya Babaei-Jadidi
    • , Dimitrios A. Garyfallos
    • , Hannes Ponstingl
    • , Joao M. L. Dias
    • , Paolo Gallipoli
    • , Michael Seiler
    • , Silvia Buonamici
    • , Binje Vick
    • , Andrew J. Bannister
    • , Roland Rad
    • , Rab K. Prinjha
    • , John C. Marioni
    • , Brian Huntly
    • , Jennifer Batson
    • , Jonathan C. Morris
    • , Cristina Pina
    • , Allan Bradley
    • , Irmela Jeremias
    • , David O. Bates
    • , Kosuke Yusa
    • , Tony Kouzarides
    •  & George S. Vassiliou
  • Article | | open

    RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.

    • Jie Zheng
    • , Chen Wang
    • , Mi Ra Chang
    • , Swapnil C. Devarkar
    • , Brandon Schweibenz
    • , Gogce C. Crynen
    • , Ruben D. Garcia-Ordonez
    • , Bruce D. Pascal
    • , Scott J. Novick
    • , Smita S. Patel
    • , Joseph Marcotrigiano
    •  & Patrick R. Griffin
  • Article | | open

    Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facilitate Treg cell lineage commitment in the thymus.

    • Laurent Chorro
    • , Masako Suzuki
    • , Shu Shien Chin
    • , Tere M. Williams
    • , Erik L. Snapp
    • , Livia Odagiu
    • , Nathalie Labrecque
    •  & Grégoire Lauvau
  • Article | | open

    Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.

    • Sylvain Normand
    • , Nadine Waldschmitt
    • , Andreas Neerincx
    • , Ruben Julio Martinez-Torres
    • , Camille Chauvin
    • , Aurélie Couturier-Maillard
    • , Olivier Boulard
    • , Laetitia Cobret
    • , Fawaz Awad
    • , Ludovic Huot
    • , Andre Ribeiro-Ribeiro
    • , Katja Lautz
    • , Richard Ruez
    • , Myriam Delacre
    • , Clovis Bondu
    • , Martin Guilliams
    • , Charlotte Scott
    • , Anthony Segal
    • , Serge Amselem
    • , David Hot
    • , Sonia Karabina
    • , Erwin Bohn
    • , Bernhard Ryffel
    • , Lionel F. Poulin
    • , Thomas A. Kufer
    •  & Mathias Chamaillard
  • Article | | open

    During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.

    • Sean Matthew McCauley
    • , Kyusik Kim
    • , Anetta Nowosielska
    • , Ann Dauphin
    • , Leonid Yurkovetskiy
    • , William Edward Diehl
    •  & Jeremy Luban
  • Article | | open

    Antigen present and presented in the structures of the skin can result in immune responses that elicit tolerance, protective immunity or allergy, depending on the immunological context. Here the authors describe a key role for the hair follicle and CD11b+ dendritic cells in the priming of local antigenic tolerance.

    • Leticia Tordesillas
    • , Daniel Lozano-Ojalvo
    • , David Dunkin
    • , Lucie Mondoulet
    • , Judith Agudo
    • , Miriam Merad
    • , Hugh A. Sampson
    •  & M. Cecilia Berin
  • Article | | open

    The antibody response during infection with dengue virus is a key component involved in the pathogenesis during secondary infection. Here the authors show antibodies targeting NS1 and the epitopes targeted can be associated with disease severity during human infection.

    • Deshni Jayathilaka
    • , Laksiri Gomes
    • , Chandima Jeewandara
    • , Geethal. S. Bandara Jayarathna
    • , Dhanushka Herath
    • , Pathum Asela Perera
    • , Samitha Fernando
    • , Ananda Wijewickrama
    • , Clare S. Hardman
    • , Graham S. Ogg
    •  & Gathsaurie Neelika Malavige
  • Article | | open

    Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation.

    • Sulayman Benmerzoug
    • , Stéphanie Rose
    • , Badreddine Bounab
    • , David Gosset
    • , Laure Duneau
    • , Pauline Chenuet
    • , Lucile Mollet
    • , Marc Le Bert
    • , Christopher Lambers
    • , Silvana Geleff
    • , Michael Roth
    • , Louis Fauconnier
    • , Delphine Sedda
    • , Clarisse Carvalho
    • , Olivier Perche
    • , David Laurenceau
    • , Bernhard Ryffel
    • , Lionel Apetoh
    • , Ahmet Kiziltunc
    • , Hakan Uslu
    • , Fadime Sultan Albez
    • , Metin Akgun
    • , Dieudonnée Togbe
    •  & Valerie F. J. Quesniaux