Parasite physiology

  • Article | | open

    Apicomplexans are parasites that use membrane transporters to scavenge essential nutrients from the host. Here the authors identify and characterize two apicomplexans transporters showing that these are crucial for cationic amino acid uptake, parasite survival and virulence.

    • Esther Rajendran
    • , Sanduni V. Hapuarachchi
    • , Catherine M. Miller
    • , Stephen J. Fairweather
    • , Yeping Cai
    • , Nicholas C. Smith
    • , Ian A. Cockburn
    • , Stefan Bröer
    • , Kiaran Kirk
    •  & Giel G. van Dooren
  • Article | | open

    Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.

    • Marek Cyrklaff
    • , Sirikamol Srismith
    • , Britta Nyboer
    • , Kvetoslava Burda
    • , Angelika Hoffmann
    • , Felix Lasitschka
    • , Sophie Adjalley
    • , Cyrille Bisseye
    • , Jacques Simpore
    • , Ann-Kristin Mueller
    • , Cecilia P. Sanchez
    • , Friedrich Frischknecht
    •  & Michael Lanzer
  • Article | | open

    Inflammatory response to malaria pathogen Plasmodium falciparum can be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties.

    • Pierre-Yves Mantel
    • , Daisy Hjelmqvist
    • , Michael Walch
    • , Solange Kharoubi-Hess
    • , Sandra Nilsson
    • , Deepali Ravel
    • , Marina Ribeiro
    • , Christof Grüring
    • , Siyuan Ma
    • , Prasad Padmanabhan
    • , Alexander Trachtenberg
    • , Johan Ankarklev
    • , Nicolas M. Brancucci
    • , Curtis Huttenhower
    • , Manoj T. Duraisingh
    • , Ionita Ghiran
    • , Winston P. Kuo
    • , Luis Filgueira
    • , Roberta Martinelli
    •  & Matthias Marti
  • Article | | open

    Iron is an essential nutrient but, in high concentrations, it is also toxic to cells. Here, Slavic et al. identify an iron transporter in malaria parasites that plays a major role in iron detoxification and is required for the parasite’s normal development.

    • Ksenija Slavic
    • , Sanjeev Krishna
    • , Aparajita Lahree
    • , Guillaume Bouyer
    • , Kirsten K. Hanson
    • , Iset Vera
    • , Jon K. Pittman
    • , Henry M. Staines
    •  & Maria M. Mota
  • Article |

    Malaria parasites generate metabolic energy through anaerobic glycolysis, yielding lactate that is then secreted out of the parasite cell by an unknown transporter. Here, Marchetti et al. identify and characterize a transporter that may be carrying out such a function in Plasmodium.

    • Rosa V. Marchetti
    • , Adele M. Lehane
    • , Sarah H. Shafik
    • , Markus Winterberg
    • , Rowena E. Martin
    •  & Kiaran Kirk
  • Article |

    Production of male and female forms of the malaria parasite in an infected person is crucial for transmission of the disease. Here, Tran et al. show that an ABC transporter protein of the parasite, expressed in the female cells, modulates lipid accumulation and formation of sexual cells.

    • Phuong N. Tran
    • , Simon H. J. Brown
    • , Todd W. Mitchell
    • , Kai Matuschewski
    • , Paul J. McMillan
    • , Kiaran Kirk
    • , Matthew W. A. Dixon
    •  & Alexander G. Maier
  • Article |

    The malaria parasite uses the methylerythritol phosphate (MEP) pathway to synthesize crucial isoprenoid metabolites. Here the authors identify and characterize a sugar phosphatase that regulates the MEP pathway by indirectly regulating the levels of isoprenoid precursors.

    • Ann M. Guggisberg
    • , Jooyoung Park
    • , Rachel L. Edwards
    • , Megan L. Kelly
    • , Dana M. Hodge
    • , Niraj H. Tolia
    •  & Audrey R. Odom
  • Article |

    The mitochondrial calcium uniporter supports oxidative phosphorylation in mammals; however, it is also present in blood-stage trypanosomes, which lack a functional respiratory chain. Huang et al. show that the mitochondrial calcium uniporter is essential for blood-stage survival and metabolism in Trypanosoma brucei.

    • Guozhong Huang
    • , Anibal E. Vercesi
    •  & Roberto Docampo