Parasite immune evasion

  • Article | | open

    In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.

    • Allison J. Bancroft
    • , Colin W. Levy
    • , Thomas A. Jowitt
    • , Kelly S. Hayes
    • , Seona Thompson
    • , Edward A. Mckenzie
    • , Matthew D. Ball
    • , Eamon Dubaissi
    • , Aidan P. France
    • , Bruno Bellina
    • , Catherine Sharpe
    • , Aleksandr Mironov
    • , Sheila L. Brown
    • , Peter C. Cook
    • , Andrew S. MacDonald
    • , David J. Thornton
    •  & Richard K. Grencis
  • Article | | open

    Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a short period of time during the process.

    • Jason Pinger
    • , Shanin Chowdhury
    •  & F. Nina Papavasiliou