Parasite host response

The parasite host response is the process by which a host interacts with and responds to parasites that it encounters. It includes various mechanisms, including immune mechanisms that are elicited in an attempt to eliminate the parasite or halt its growth.

Latest Research and Reviews

News and Comment

  • News & Views |

    A promising vaccine fails to provide durable protection against infection and clinical malaria in infants, a key malaria vaccine target population, in a phase 2b clinical trial. The need for a highly effective vaccine against malaria remains as urgent as ever.

    • Irene N. Nkumama
    •  & Faith H. A. Osier
    Nature Microbiology 6, 1345-1346
  • News & Views |

    Malaria causes many changes in human metabolism, although the extent to which these changes underpin pathology and the host immune response remains poorly understood. In this issue of Nature Metabolism, Abdrabou et al. show that malaria is associated with elevated levels of circulating steroids in susceptible children and propose that these immunosuppressive lipids exacerbate disease.

    • Malcolm J. McConville
    •  & Christian R. Engwerda
    Nature Metabolism 3, 892-893
  • News & Views |

    Duffy-binding protein (DBP) is the leading vaccine candidate for Plasmodium vivax malaria. Two studies express and characterise the first human monoclonal antibodies against DBP, induced by natural infection and vaccination, showing they have in vitro functional activity but target different conserved epitopes.

    • Jack S. Richards
    •  & Paul A. Ramsland
    Nature Microbiology 4, 1428-1429
  • News & Views |

    In recent years, there has been a growing appreciation of the role metabolism plays in controlling nearly all aspects of cellular function. Three recent articles explore how host metabolic cues influence different aspects of Plasmodium biology during infection, including parasite growth and sexual differentiation.

    • Kim C. Williamson
    • , Rodney L. Levine
    •  & Louis H. Miller
    Nature Microbiology 3, 130-131