Parasite genomics articles from across Nature Portfolio

Host-parasite interactions can lead to negative frequency-dependent selection. Here, the authors sequence the genomes of H. bakeri and H. polygyrus, parasites of house and wood mice, respectively, and find that proteins that interact with the host immune response are often highly diverse.

Evaluation of a nanopore-sequencing-based workflow for detection of antimalarial resistance in Ghana demonstrates feasibility where molecular surveillance is needed.

Plasmodium falciparum candidate artemisinin partial-resistance Kelch13 622I mutation co-occurs with pfhrp2/3 deletions in Ethiopia.

Studying malaria transmission biology using scRNA-sequencing provides information on within-host strain diversity and transcriptional states. Here, we comment on our collaborative efforts at establishing single-cell capacities in sub-Saharan Africa and the challenges encountered in Mali’s endemic setting.

This month’s Genome Watch highlights approaches that enable high-resolution mapping of transcription start sites in apicomplexan parasites.

A large-scale comparative genomic survey of Cryptosporidium species and subtypes reveals a cryptic anthroponotic Cryptosporidium parvum branch and a large, recent superclade of species and subtypes that undergo genetic exchange, potentially facilitating host associations.

This month’s Genome Watch explores the genetic variability of the anti-malaria vaccine protein and discusses its significance for an efficacious intervention.

This study reports whole genomes for all known Laverania species, providing insights into the emergence of Plasmodium falciparum as a major human pathogen.