Paget disease articles from across Nature Portfolio

Paget disease is a metabolic bone disorder characterized by focal increases in bone remodelling, marked by excessive osteoclastic bone resorption and increased bone formation. Despite having increased mass, the bone produced is structurally disorganized and mechanically weak, and can result in bone pain, arthritis, bone deformity and fracture.

Latest Research and Reviews

Research
31 January 2019 | Open Access

Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget’s disease of bone
- Benjamin H. Mullin
- , Kun Zhu
- & Scott G. Wilson
Scientific Reports 9, 1052
Research
19 May 2017 | Open Access

A FKBP5 mutation is associated with Paget’s disease of bone and enhances osteoclastogenesis
- Bingru Lu
- , Yulian Jiao
- & Yueran Zhao
Experimental & Molecular Medicine 49, e336
Research
11 July 2016 | Open Access

Otosclerosis Associated with a De Novo Mutation −832G > A in the TGFB1 Gene Promoter Causing a Decreased Expression Level
- Saurabh Priyadarshi
- , Kirtal Hansdah
- & Puppala Venkat Ramchander
Scientific Reports 6, 29572
Reviews | 18 August 2015

Paget's disease of bone—genetic and environmental factors

Paget's disease is a disorder of bone that manifests in one or several bones and is initiated by osteoclast-induced osteolytic lesions. In addition to a genetic cause, environmental factors, including measles virus, have been proposed to have a role in the pathogenesis of Paget's disease. Here, Frederick R. Singer discusses the present knowledge and controversies surrounding the aetiology of Paget's disease.
- Frederick R. Singer
Nature Reviews Endocrinology 11, 662-671
Research | 25 February 2013

CXCL5 stimulation of RANK ligand expression in Paget’s disease of bone
- Kumaran Sundaram
- , D Sudhaker Rao
- & Sakamuri V Reddy
Laboratory Investigation 93, 472-479
Research
17 July 2012 | Open Access

Effect of Paget’s disease of bone (osteitis deformans) on the progression of prostate cancer bone metastasis
- S-M Tu
- , A Som
- & S-CJ Yeung
British Journal of Cancer 107, 646-651

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News and Comment

News & Views | 01 September 2010

Do all Paget disease risk genes incriminate the osteoclast?

A key component of Paget disease of bone is a localized increase in osteoclastic activity, which might be attributable, in part, to mutations in the sequestosome 1 gene. A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable.
- Frederick R. Singer
- & Robin J. Leach
Nature Reviews Rheumatology 6, 502-503

All News & Comment

Paget disease articles from across Nature Portfolio

Latest Research and Reviews

Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget’s disease of bone

A FKBP5 mutation is associated with Paget’s disease of bone and enhances osteoclastogenesis

Otosclerosis Associated with a De Novo Mutation −832G > A in the TGFB1 Gene Promoter Causing a Decreased Expression Level

Paget's disease of bone—genetic and environmental factors

CXCL5 stimulation of RANK ligand expression in Paget’s disease of bone

Effect of Paget’s disease of bone (osteitis deformans) on the progression of prostate cancer bone metastasis

News and Comment

Do all Paget disease risk genes incriminate the osteoclast?

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