Oxidoreductases articles from across Nature Portfolio

Oxidoreductases are enzymes that catalyze transfer of electrons from a donor (reductant) to an acceptor (oxidant) molecule, generally using nicotinamide adenine dinucleotide phosphate (NADP) or nicotinamide adenine dinucleotide (NAD+) as cofactors. The name of the oxidoreductase generally takes the form of '[acceptor name] dehydrogenase'.

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News and Comment

  • News & Views |

    Converting simple building blocks into enantiopure amines is an important synthetic transformation. Now, a biocatalyst has been discovered that catalyses two reductive steps within a single active site, and can synthesize a range of amine targets from ene–one starting materials.

    • Michael A. Herrera
    •  & Dominic J. Campopiano
    Nature Synthesis 1, 420-421
  • News & Views |

    Nitrogenase reduces dinitrogen at one of its iron–sulfur cores to produce ammonia by a convoluted mechanism. Now, research highlights the importance of sulfur mobility on one of nitrogenase’s metallocofactors for nitrogen fixation.

    • Ross D. Milton
    Nature Catalysis 5, 361-362
  • News & Views |

    Levine and colleagues demonstrate that the effects of caloric restriction on hepatic gene expression, circulating acylcarnitines and body temperature are largely mediated by an increase in the daytime peak of NADH concentration in the liver.

    • Karthikeyani Chellappa
    •  & Joseph A. Baur
    Nature Metabolism 3, 1589-1590
  • News & Views |

    Conventional experiments for generating proteins with improved properties by directed evolution are iterative, lengthy and costly. Now, a label-free assay has been developed for ultrahigh-throughput microfluidic screening that can dramatically accelerate the discovery of superior biocatalysts from a single round of genetic randomization.

    • Wolf-Dieter Fessner
    Nature Catalysis 2, 738-739