Osteoarthritis articles within Nature Reviews Rheumatology

Featured

  • Review Article |

    Early identification of osteoarthritis (OA) prior to the development of symptoms is challenging. Post-traumatic OA provides a model for the development of OA following a defined event. In this Review, the authors describe the existing knowledge relating to the biomarkers of post-traumatic OA, which might also be applicable to the identification of early non-traumatic OA.

    • Virginia Byers Kraus
    •  & Ming-Feng Hsueh

  • Research Highlight |

    A nanoparticle-based formulation of the anticancer drug pazopanib, which inhibits VEGFR1 and VEGFR2, shows promise as a disease-modifying drug for osteoarthritis.

    • Rebecca Kelsey

  • News & Views |

    EULAR’s 2023 updated recommendations for the non-pharmacological treatment of hip and knee osteoarthritis reiterates and confirms, in an abbreviated form, what we have known for more than a decade. Unfortunately, the abbreviated format of the updated recommendations lacks specificity and clinical usefulness. More detailed guidance could have facilitated wider uptake and improved care.

    • Marius Henriksen

  • Research Highlight |

    New research has identified apolipoprotein E expressed by fibroblasts and macrophages in the infrapatellar fat pad and synovium as a pathogenetic mediator and potential therapeutic target in knee osteoarthritis.

    • Robert Phillips

  • News & Views |

    The World Health Organization (WHO) has published new guidelines for the non-surgical management of chronic primary low back pain in adults in primary and community care settings. Although the guidelines are commendable, they lack guidance on when to suspect and how to avoid missing important secondary causes of back pain.

    • Mohamad Bittar
    •  & Atul Deodhar

  • Research Highlight |

    The voltage-gated sodium channel Nav1.7 is expressed on chondrocytes, regulates chondrocyte biology and osteoarthritis progression, and is a promising dual target for modifying disease while providing pain relief in osteoarthritis.

    • Jessica McHugh

  • News & Views |

    New findings suggest that current cell therapy approaches are not superior to a simple corticosteroid injection for the treatment of osteoarthritis, calling into question the role of existing cell therapies and highlighting the need for further research and development in this field.

    • Scott A. Rodeo

  • Research Highlight |

    Methotrexate reduces pain and stiffness in hand osteoarthritis with synovitis, according to the results of a new randomized controlled trial.

    • Jessica McHugh

  • Review Article |

    Extracellular vesicles derived from mesenchymal stromal cells provide the therapeutic benefits of the parental cells with advantages relating to immunogenicity and ease of handling. This Review discusses the therapeutic potential of native and modified extracellular vesicles for the treatment of rheumatic diseases, focusing on osteoarthritis and rheumatoid arthritis.

    • Giuliana Minani Bertolino
    • , Marie Maumus
    •  & Danièle Noël

  • Research Highlight |

    Researchers have developed ‘urchin-like’ ceria nanoparticles with inherent antioxidant properties that efficiently carry therapeutic microRNA, enabling gene therapy following intra-articular injection in a mouse model of osteoarthritis.

    • Robert Phillips

  • Research Highlight |

    A new treatment for osteoarthritis that combines cells from the patient in vitro prior to intra-articular injection has demonstrated beneficial effects on arthritic joints in a compassionate use study.

    • Robert Phillips

  • News & Views |

    Given that intra-articular injections for the knee of treatments such as hyaluronic acid, stem cells and platelet-rich plasma are advised against or only weakly recommended by current clinical-practice guidelines, why do people continue to seek information about these treatments?

    • Vicky Duong
    •  & David J. Hunter

  • Research Highlight |

    Protein phosphatase magnesium-dependent 1A is a negative modulator of transforming growth factor β signalling and a potential new therapeutic target in osteoarthritis.

    • Jessica McHugh

  • Research Highlight |

    Age-related stiffening of the extracellular matrix in cartilage promotes chondrocyte ageing in an epigenetically controlled process involving repression of the longevity protein α-Klotho.

    • Jessica McHugh

  • Research Highlight |

    IKKε, an upstream regulator of the NF-κB signalling pathway, mediates cartilage degradation in a mouse model of osteoarthritis and is a potential therapeutic target.

    • Jessica McHugh

  • Research Highlight |

    New research suggests that impaired synovial lymphatic function contributes to the pathogenesis of age-related osteoarthritis and could represent a new therapeutic target.

    • Sarah Onuora

  • Research Highlight |

    A calcium-binding peptide derived from fetuin-A inhibited pathological cartilage calcification in an experimental model of osteoarthritis, suggesting therapeutic potential.

    • Sarah Onuora

  • Research Highlight |

    A novel strategy for the repair of articular cartilage involves converting fibrocartilage to hyaline cartilage by modifying the cytoskeleton of fibrotic chondrocytes.

    • Sarah Onuora

  • Review Article |

    Cartilage calcification is a hallmark of osteoarthritis. In this Review, the authors discuss the molecular mechanisms of calcium crystal formation in chondrocytes, the effects of crystals on cells in the joint, and potential targets for the treatment of osteoarthritis and other calcification disorders.

    • Ilaria Bernabei
    • , Alexander So
    •  & Sonia Nasi

  • Research Highlight |

    New research in a mouse model of osteoarthritis shows that the RNA-binding protein Lin28a is expressed in chondrocytes and limits cartilage damage by inhibition of Let-7 microRNAs.

    • Robert Phillips

  • Research Highlight |

    New research demonstrates that a hydrogel-based miRNA delivery system might have therapeutic potential to treat osteoarthritis by targeting chondrocyte senescence.

    • Michael Attwaters

  • Research Highlight |

    A machine learning approach has been used to identify three distinct osteoarthritis endotypes based on biochemical markers related to joint tissue processes.

    • Michael Attwaters

  • Review Article |

    This Review examines the biology of synovial inflammation, the cell types involved, their interactions and the role of synovitis in the development and progression of osteoarthritis.

    • Elsa Sanchez-Lopez
    • , Roxana Coras
    •  & Monica Guma

  • Review Article |

    Erosive hand osteoarthritis is an aggressive condition with poor outcomes. In this Review, the authors describe the clinical features and risk factors associated with erosive hand osteoarthritis, and summarize progress in the areas of biomarkers, imaging, classification criteria and treatment.

    • Marta Favero
    • , Elisa Belluzzi
    •  & Roberta Ramonda

  • Research Highlight |

    In a rabbit model of osteoarthritis, cartilage regeneration was promoted by a biodegradable implant that generates a piezoelectric response during physical exercise.

    • Sarah Onuora

  • Review Article |

    In this Review, Paggi et al. discuss the requirements and challenges in engineering a joint-on-chip device, propose an architecture for such a model of the joint and highlight the potential for these platforms to further advance insight into arthritic diseases and facilitate drug development.

    • Carlo Alberto Paggi
    • , Liliana Moreira Teixeira
    •  & Marcel Karperien

  • Review Article |

    The pathways involved in sensing and responding to mechanical stimuli have important roles in maintaining cartilage health, and can contribute to disease when dysregulated. This Review discusses cartilage mechanosignalling pathways and how they can be targeted to treat osteoarthritis.

    • Tom Hodgkinson
    • , Domhnall C. Kelly
    •  & Fergal J. O’Brien

  • Review Article |

    Knee joint distraction (KJD) is used to stimulate joint repair in advanced osteoarthritis. In the Review, Jansen and Mastbergen provide an overview of the clinical trial results of KJD treatment, current knowledge of the molecular mechanisms underlying joint repair in KJD, and future directions and unanswered questions in KJD research and treatment.

    • Mylène P. Jansen
    •  & Simon C. Mastbergen

  • Review Article |

    Non-coding RNAs such as microRNAs, long non-coding RNAs and circular RNAs regulate signalling pathways that are important in joint development, homeostasis and disease. A better understanding of the non-coding RNA interactome could lead to new therapies for joint diseases.

    • Shabana A. Ali
    • , Mandy J. Peffers
    •  & Mohit Kapoor

  • Research Highlight |

    New research shows that cartilage engineered from nasal chondrocytes can integrate with osteoarthritic joint tissues in animal models, and provides early evidence of clinical benefits in patients with knee osteoarthritis.

    • Robert Phillips

  • Research Highlight |

    Targeted nanoparticles that bind to exposed type II collagen in injured joints and promote localized downregulation of Mmp13 expression represent progress towards a disease-modifying osteoarthritis drug.

    • Robert Phillips

  • Review Article |

    In this Review, the authors assess the current understanding of symptomatic early-stage knee osteoarthritis, including its diagnosis and classification, and highlight important gaps in knowledge that will need to be addressed to enable effective management.

    • Armaghan Mahmoudian
    • , L. Stefan Lohmander
    •  & Frank P. Luyten

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