Origin selection articles within Nature

Featured

• Article
  08 June 2022 | Open Access

  Cohesin-mediated loop anchors confine the locations of human replication origins

  A study shows that the three-dimensional conformation of the human genome influences the positioning of DNA replication initiation zones, highlighting cohesin-mediated loop anchors as essential determinants of their precise location.

  • Daniel J. Emerson
  • , Peiyao A. Zhao
  •  & Jennifer E. Phillips-Cremins

• Article | 25 December 2019

  H2A.Z facilitates licensing and activation of early replication origins

  DNA replication in eukaryotes requires the histone variant H2A.Z, which binds the enzyme SUV420H1 to promote the dimethylation of histone H4, in turn recruiting the origin-recognition complex to activate early replication origins.

  • Haizhen Long
  • , Liwei Zhang
  •  & Guohong Li

• Article | 04 July 2018

  Structure of the origin recognition complex bound to DNA replication origin

  The cryo-EM structure of the yeast origin recognition complex (ORC) bound to a 72-base-pair origin DNA sequence provides insights into the basis of the origin selection mechanism.

  • Ningning Li
  • , Wai Hei Lam
  •  & Bik-Kwoon Tye

• Letter | 03 November 2013

  Accelerated growth in the absence of DNA replication origins

  When all origins of replication are deleted from the archaeon Haloferax volcanii, homologous recombination is used to initiate DNA replication and the growth rate is accelerated.

  • Michelle Hawkins
  • , Sunir Malla
  •  & Thorsten Allers