Origin firing

Origin firing is the initiation of DNA replication that takes place at specialised start sites, or replication origins, where the DNA first has to be opened up and unwound, before DNA synthesis machinery is loaded to start replication. Not all replication origins are fired at the same time

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    Replication stress fuels chromosomal instability, tumor heterogeneity and therapy resistance. The Sonic hedgehog pathway is now linked to an unorthodox form of replication stress in cerebellar granular-cell progenitors through deregulated firing of DNA replication origins, with implications for the pathogenesis, genomic instability and treatment of medulloblastoma.

    • Apolinar Maya-Mendoza
    •  & Jiri Bartek
    Nature Cancer 1, 758-760