Organogenesis

Organogenesis is the process by which the internal organs and specific structures such as the limb are formed during development of an organism. Organogenesis involves the coordination of multiple developmental processes such as embryonic induction, pattern formation, morphogenesis, cell proliferation and differentiation.

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  • News and Views |

    The mechanism underlying glomerular filtration barrier selectivity has not been resolved. A new study that reports an inverse correlation between slit diaphragm density and proteinuria in a genetic mouse model of focal segmental glomerulosclerosis suggests that podocytes function to compress the glomerular basement membrane (GBM) and that failure of this process results in GBM stretching and increased permeability.

    • Marcus J. Moeller
    •  & Arnaldo Chia-Gil
  • News and Views |

    Postmortem studies have previously suggested that adult olfactory neurogenesis occurs in humans. In new research, Durante and colleagues obtained fresh tissue from healthy adult humans via endoscopic nasal surgery and used single-cell RNA sequencing (RNA-seq) to identify the entire neurogenic trajectory in the olfactory epithelium, confirming the existence of human olfactory neurogenesis.

    • Thomas Berger
    • , Hyunah Lee
    •  & Sandrine Thuret
    Nature Neuroscience 23, 297-298
  • News and Views |

    Tangential expansion of neural stem cells in the mammalian neocortex increases the number of cortical columns. A new study shows that neural stem cells that become detached from the apical surface during division regenerate an apical endfoot to ensure tangential expansion in the early stage but later lose this ability when radial expansion occurs.

    • Masafumi Tsuboi
    •  & Yukiko Gotoh