Organelles articles within Nature

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  • Article |

    Glucocorticoids reprogram the mitochondrial metabolism of macrophages, resulting in increased and sustained production of the anti-inflammatory metabolite itaconate and, as a consequence, inhibition of the inflammatory response.

    • Jean-Philippe Auger
    • , Max Zimmermann
    •  & Gerhard Krönke

  • Article |

    The conserved HEAT repeat protein HPO-27 is identified as a lysosome scission factor in Caenorhabditis elegans, and the human homologue MROH1 also serves the same function to maintain lysosomal homeostasis.

    • Letao Li
    • , Xilu Liu
    •  & Xiaochen Wang

  • Article
    | Open Access

    The E3 ligase SIFI is identified as a dedicated silencing factor of the integrated stress response, a finding that has implications for the development of therapeutics for neurodegenerative diseases caused by mitochondrial protein import stress.

    • Diane L. Haakonsen
    • , Michael Heider
    •  & Michael Rapé

  • Article
    | Open Access

    High-speed molecular tracking is integrated with three-dimensional electron microscopy to map the diffusion distribution and ultrastructure of endoplasmic reticulum-mitochondria contact sites, revealing the ability of high-speed single-molecule imaging to map contact site interface structures and corresponding diffusion landscapes.

    • Christopher J. Obara
    • , Jonathon Nixon-Abell
    •  & Jennifer Lippincott-Schwartz

  • Article
    | Open Access

    Mitochondria have a pivotal role in the transport of dietary lipids in enterocytes, a finding that might have relevance to understanding the aberrant gastrointestinal function in patients with mitochondrial disorders.

    • Chrysanthi Moschandrea
    • , Vangelis Kondylis
    •  & Manolis Pasparakis

  • Perspective |

    The mechanisms by which mitochondria are transferred between cells and how intercellular mitochondria transfer regulates physiological processes and disease pathogenesis are discussed.

    • Nicholas Borcherding
    •  & Jonathan R. Brestoff

  • Article
    | Open Access

    A proteomics analysis demonstrates that, during nutrient stress, mammalian cells prioritize degradation by autophagy of membrane proteins and identifies receptors that mediate this process at the Golgi and also have a role in Golgi remodelling during neuronal differentiation.

    • Kelsey L. Hickey
    • , Sharan Swarup
    •  & J. Wade Harper

  • Article
    | Open Access

    Triacylglycerols are an energy source produced in humans by DGAT1 and DGAT2, but disrupting these enzymes reveals a noncanonical pathway involving the protein DIESL (formerly TMEM68) and its regulator TMX1, which is important during lipid scarcity.

    • Gian-Luca McLelland
    • , Marta Lopez-Osias
    •  & Thijn R. Brummelkamp

  • Article |

    Cryo-electron microscopy structures of OPA1, mutations of which are associated with the disease dominant optic atrophy, provide insight into how structural features of OPA1 enable this protein to mediate mitochondrial-membrane fusion and remodelling.

    • Sarah B. Nyenhuis
    • , Xufeng Wu
    •  & Jenny E. Hinshaw

  • Article |

    Human OPA1 embeds itself into cardiolipin-containing membranes through a lipid-binding paddle domain, and OPA1 oligomerization through multiple assembly interfaces promotes the helical assembly of a flexible OPA1 lattice on the membrane, driving mitochondrial fusion in cells.

    • Alexander von der Malsburg
    • , Gracie M. Sapp
    •  & Halil Aydin

  • Article
    | Open Access

    We identify a highly controlled cytosolic surveillance mechanism that integrates independent mitochondrial stress signals to initiate the mitochondrial unfolded protein response (UPR), revealing a link between mitochondrial and cytosolic proteostasis.

    • F. X. Reymond Sutandy
    • , Ines Gößner
    •  & Christian Münch

  • Article
    | Open Access

    The membrane-shaping protein ARL6IP1 is involved in the selective degradation of the endoplasmic reticulum, and this process depends on its ubiquitination and interaction with other membrane-shaping proteins such as FAM134B.

    • Hector Foronda
    • , Yangxue Fu
    •  & Christian A. Hübner

  • Article |

    Integrative structural biology combining quantitative live imaging, cryo-correlative microscopy, subtomogram averaging and molecular modelling enables in situ determination of the structure of the endoplasmic reticulum–mitochondria encounter complex in yeast.

    • Michael R. Wozny
    • , Andrea Di Luca
    •  & Wanda Kukulski

  • Article |

    A study presents evidence to support a model in which liquid–liquid phase separation of components of the transport machinery mediates formation of transient protein transport channels on peroxisomes.

    • Rini Ravindran
    • , Isabel O. L. Bacellar
    •  & Stephen W. Michnick

  • Article
    | Open Access

    A study describing an approach that combines imaging and profiling techniques to structurally and functionally analyse lung cancer in vivo, revealing heterogeneous mitochondrial networks and an association between bioenergetic phenotypes and mitochondrial organization and function.

    • Mingqi Han
    • , Eric A. Bushong
    •  & David B. Shackelford

  • Article
    | Open Access

    Fumarate metabolism regulates the innate immune response through a mechanism in which high levels of fumarate result in the generation of mitochondrial-derived vesicles and the release of mitochondrial DNA into the cytosol, which activates inflammatory pathways.

    • Vincent Zecchini
    • , Vincent Paupe
    •  & Christian Frezza

  • Article
    | Open Access

    An analysis of MitCOM—a comprehensive resource for the identification, organization and interaction of mitochondrial machineries and pathways in yeast—identifies a constitutive pathway for the removal of preproteins.

    • Uwe Schulte
    • , Fabian den Brave
    •  & Thomas Becker

  • Article |

    An adipocyte-selective product of the Clstn3 locus (CLSTN3β) facilitates the use of stored triglyceride by limiting lipid droplet (LD) expansion, defining a molecular mechanism that regulates LD form and function to facilitate lipid utilization in thermogenic adipocytes.

    • Kevin Qian
    • , Marcus J. Tol
    •  & Peter Tontonoz

  • Article |

    The lysosomal transmembrane protein CLN3 is required for the lysosomal clearance of glycerophosphodiesters in mice and in human cells, suggesting that the loss of CLN3 causes Batten disease in children due to defects in glycerophospholipid metabolism.

    • Nouf N. Laqtom
    • , Wentao Dong
    •  & Monther Abu-Remaileh

  • Article |

    The non-structural protein NSP6 in SARS-CoV-2 has a key role in viral replication by zippering the endoplasmic reticulum membrane to establish connectors between the double-membrane vesicles of the viral replication organelle and the endoplasmic reticulum.

    • Simona Ricciardi
    • , Andrea Maria Guarino
    •  & Maria Antonietta De Matteis

  • Article |

    Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.

    • Güneş Parlakgül
    • , Ana Paula Arruda
    •  & Gökhan S. Hotamışlıgil

  • Article
    | Open Access

    The endoplasmic reticulum proteins CLIMP63, kinectin and p180 bind preferentially to subsets of microtubules with different post-translational modifications, thereby linking the ‘tubulin code’ to the intracellular distribution of membrane organelles.

    • Pengli Zheng
    • , Christopher J. Obara
    •  & Craig Blackstone

  • Article |

    Focused ion beam scanning electron microscopy (FIB-SEM) combined with deep-learning-based segmentation is used to produce three-dimensional reconstructions of complete cells and tissues, in which up to 35 different organelle classes are annotated.

    • Larissa Heinrich
    • , Davis Bennett
    •  & Destiny Nguyen

  • Article |

    In the eye lens of zebrafish and mice, the phospholipases Plaat1 and PLAAT3, respectively, are essential for macroautophagy-independent organelle degradation that produces an organelle-free zone and achieves optimal transparency.

    • Hideaki Morishita
    • , Tomoya Eguchi
    •  & Noboru Mizushima

  • Article
    | Open Access

    Depriving unicellular Dictyostelium discoideum of nutrients generates reactive oxygen species that sequester cysteine within glutathione, which maintains this amoeba in a nonproliferating state that promotes aggregation into a multicellular organism.

    • Beth Kelly
    • , Gustavo E. Carrizo
    •  & Erika L. Pearce

  • Review Article |

    The functional and regulatory aspects of the ‘mitochondrial divisome’ are separated into core and accessory machinery, thus providing a mechanistic understanding of the process of mitochondrial fission.

    • Felix Kraus
    • , Krishnendu Roy
    •  & Michael T. Ryan

  • Article |

    Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.

    • Nina A. Bonekamp
    • , Bradley Peter
    •  & Nils-Göran Larsson

  • Article |

    A rapid labelling and immunopurification-based method is used to isolate melanosomes and profile their labile metabolites, revealing that MFSD12 has a key role in cysteine import into melanosomes and lysosomes.

    • Charles H. Adelmann
    • , Anna K. Traunbauer
    •  & David M. Sabatini

  • Article |

    The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether phospholipids, and changes in the abundances of these lipids are associated with altered sensitivity to ferroptosis during cell-state transitions.

    • Yilong Zou
    • , Whitney S. Henry
    •  & Stuart L. Schreiber

  • Article |

    SLC25A51 is identified as a transporter of intact NAD+ into mammalian mitochondria and is required to maintain the mitochondrial NAD+ pool and respiratory function.

    • Timothy S. Luongo
    • , Jared M. Eller
    •  & Joseph A. Baur

  • Article |

    A protein condensate formed by multivalent interactions between the long non-coding RNA Xist and specific RNA-binding proteins drives the compartmentalization required to perpetuate gene silencing on the inactive X chromosome.

    • Amy Pandya-Jones
    • , Yolanda Markaki
    •  & Kathrin Plath

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