Oncology

Definition

Oncology is the branch of medicine that deals with the diagnosis and treatment of cancer. It includes medical oncology (the use of chemotherapy, hormone therapy, and other drugs to treat cancer), radiation oncology (the use of radiation therapy to treat cancer), and surgical oncology (the use of surgery and other procedures to treat cancer).

Featured

Latest Research and Reviews

  • Research |

    Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.

    • Kyriaki Michailidou
    • , Sara Lindström
    • , Joe Dennis
    • , Jonathan Beesley
    • , Shirley Hui
    • , Siddhartha Kar
    • , Audrey Lemaçon
    • , Penny Soucy
    • , Dylan Glubb
    • , Asha Rostamianfar
    • , Manjeet K. Bolla
    • , Qin Wang
    • , Jonathan Tyrer
    • , Ed Dicks
    • , Andrew Lee
    • , Zhaoming Wang
    • , Jamie Allen
    • , Renske Keeman
    • , Ursula Eilber
    • , Juliet D. French
    • , Xiao Qing Chen
    • , Laura Fachal
    • , Karen McCue
    • , Amy E. McCart Reed
    • , Maya Ghoussaini
    • , Jason S. Carroll
    • , Xia Jiang
    • , Hilary Finucane
    • , Marcia Adams
    • , Muriel A. Adank
    • , Habibul Ahsan
    • , Kristiina Aittomäki
    • , Hoda Anton-Culver
    • , Natalia N. Antonenkova
    • , Volker Arndt
    • , Kristan J. Aronson
    • , Banu Arun
    • , Paul L. Auer
    • , François Bacot
    • , Myrto Barrdahl
    • , Caroline Baynes
    • , Matthias W. Beckmann
    • , Sabine Behrens
    • , Javier Benitez
    • , Marina Bermisheva
    • , Leslie Bernstein
    • , Carl Blomqvist
    • , Natalia V. Bogdanova
    • , Stig E. Bojesen
    • , Bernardo Bonanni
    • , Anne-Lise Børresen-Dale
    • , Judith S. Brand
    • , Hiltrud Brauch
    • , Paul Brennan
    • , Hermann Brenner
    • , Louise Brinton
    • , Per Broberg
    • , Ian W. Brock
    • , Annegien Broeks
    • , Angela Brooks-Wilson
    • , Sara Y. Brucker
    • , Thomas Brüning
    • , Barbara Burwinkel
    • , Katja Butterbach
    • , Qiuyin Cai
    • , Hui Cai
    • , Trinidad Caldés
    • , Federico Canzian
    • , Angel Carracedo
    • , Brian D. Carter
    • , Jose E. Castelao
    • , Tsun L. Chan
    • , Ting-Yuan David Cheng
    • , Kee Seng Chia
    • , Ji-Yeob Choi
    • , Hans Christiansen
    • , Christine L. Clarke
    • , NBCS Collaborators
    • , Margriet Collée
    • , Don M. Conroy
    • , Emilie Cordina-Duverger
    • , Sten Cornelissen
    • , David G. Cox
    • , Angela Cox
    • , Simon S. Cross
    • , Julie M. Cunningham
    • , Kamila Czene
    • , Mary B. Daly
    • , Peter Devilee
    • , Kimberly F. Doheny
    • , Thilo Dörk
    • , Isabel dos-Santos-Silva
    • , Martine Dumont
    • , Lorraine Durcan
    • , Miriam Dwek
    • , Diana M. Eccles
    • , Arif B. Ekici
    • , A. Heather Eliassen
    • , Carolina Ellberg
    • , Mingajeva Elvira
    • , Christoph Engel
    • , Mikael Eriksson
    • , Peter A. Fasching
    • , Jonine Figueroa
    • , Dieter Flesch-Janys
    • , Olivia Fletcher
    • , Henrik Flyger
    • , Lin Fritschi
    • , Valerie Gaborieau
    • , Marike Gabrielson
    • , Manuela Gago-Dominguez
    • , Yu-Tang Gao
    • , Susan M. Gapstur
    • , José A. García-Sáenz
    • , Mia M. Gaudet
    • , Vassilios Georgoulias
    • , Graham G. Giles
    • , Gord Glendon
    • , Mark S. Goldberg
    • , David E. Goldgar
    • , Anna González-Neira
    • , Grethe I. Grenaker Alnæs
    • , Mervi Grip
    • , Jacek Gronwald
    • , Anne Grundy
    • , Pascal Guénel
    • , Lothar Haeberle
    • , Eric Hahnen
    • , Christopher A. Haiman
    • , Niclas Håkansson
    • , Ute Hamann
    • , Nathalie Hamel
    • , Susan Hankinson
    • , Patricia Harrington
    • , Steven N. Hart
    • , Jaana M. Hartikainen
    • , Mikael Hartman
    • , Alexander Hein
    • , Jane Heyworth
    • , Belynda Hicks
    • , Peter Hillemanns
    • , Dona N. Ho
    • , Antoinette Hollestelle
    • , Maartje J. Hooning
    • , Robert N. Hoover
    • , John L. Hopper
    • , Ming-Feng Hou
    • , Chia-Ni Hsiung
    • , Guanmengqian Huang
    • , Keith Humphreys
    • , Junko Ishiguro
    • , Hidemi Ito
    • , Motoki Iwasaki
    • , Hiroji Iwata
    • , Anna Jakubowska
    • , Wolfgang Janni
    • , Esther M. John
    • , Nichola Johnson
    • , Kristine Jones
    • , Michael Jones
    • , Arja Jukkola-Vuorinen
    • , Rudolf Kaaks
    • , Maria Kabisch
    • , Katarzyna Kaczmarek
    • , Daehee Kang
    • , Yoshio Kasuga
    • , Michael J. Kerin
    • , Sofia Khan
    • , Elza Khusnutdinova
    • , Johanna I. Kiiski
    • , Sung-Won Kim
    • , Julia A. Knight
    • , Veli-Matti Kosma
    • , Vessela N. Kristensen
    • , Ute Krüger
    • , Ava Kwong
    • , Diether Lambrechts
    • , Loic Le Marchand
    • , Eunjung Lee
    • , Min Hyuk Lee
    • , Jong Won Lee
    • , Chuen Neng Lee
    • , Flavio Lejbkowicz
    • , Jingmei Li
    • , Jenna Lilyquist
    • , Annika Lindblom
    • , Jolanta Lissowska
    • , Wing-Yee Lo
    • , Sibylle Loibl
    • , Jirong Long
    • , Artitaya Lophatananon
    • , Jan Lubinski
    • , Craig Luccarini
    • , Michael P. Lux
    • , Edmond S. K. Ma
    • , Robert J. MacInnis
    • , Tom Maishman
    • , Enes Makalic
    • , Kathleen E. Malone
    • , Ivana Maleva Kostovska
    • , Arto Mannermaa
    • , Siranoush Manoukian
    • , JoAnn E. Manson
    • , Sara Margolin
    • , Shivaani Mariapun
    • , Maria Elena Martinez
    • , Keitaro Matsuo
    • , Dimitrios Mavroudis
    • , James McKay
    • , Catriona McLean
    • , Hanne Meijers-Heijboer
    • , Alfons Meindl
    • , Primitiva Menéndez
    • , Usha Menon
    • , Jeffery Meyer
    • , Hui Miao
    • , Nicola Miller
    • , Nur Aishah Mohd Taib
    • , Kenneth Muir
    • , Anna Marie Mulligan
    • , Claire Mulot
    • , Susan L. Neuhausen
    • , Heli Nevanlinna
    • , Patrick Neven
    • , Sune F. Nielsen
    • , Dong-Young Noh
    • , Børge G. Nordestgaard
    • , Aaron Norman
    • , Olufunmilayo I. Olopade
    • , Janet E. Olson
    • , Håkan Olsson
    • , Curtis Olswold
    • , Nick Orr
    • , V. Shane Pankratz
    • , Sue K. Park
    • , Tjoung-Won Park-Simon
    • , Rachel Lloyd
    • , Jose I. A. Perez
    • , Paolo Peterlongo
    • , Julian Peto
    • , Kelly-Anne Phillips
    • , Mila Pinchev
    • , Dijana Plaseska-Karanfilska
    • , Ross Prentice
    • , Nadege Presneau
    • , Darya Prokofyeva
    • , Elizabeth Pugh
    • , Katri Pylkäs
    • , Brigitte Rack
    • , Paolo Radice
    • , Nazneen Rahman
    • , Gadi Rennert
    • , Hedy S. Rennert
    • , Valerie Rhenius
    • , Atocha Romero
    • , Jane Romm
    • , Kathryn J. Ruddy
    • , Thomas Rüdiger
    • , Anja Rudolph
    • , Matthias Ruebner
    • , Emiel J. T. Rutgers
    • , Emmanouil Saloustros
    • , Dale P. Sandler
    • , Suleeporn Sangrajrang
    • , Elinor J. Sawyer
    • , Daniel F. Schmidt
    • , Rita K. Schmutzler
    • , Andreas Schneeweiss
    • , Minouk J. Schoemaker
    • , Fredrick Schumacher
    • , Peter Schürmann
    • , Rodney J. Scott
    • , Christopher Scott
    • , Sheila Seal
    • , Caroline Seynaeve
    • , Mitul Shah
    • , Priyanka Sharma
    • , Chen-Yang Shen
    • , Grace Sheng
    • , Mark E. Sherman
    • , Martha J. Shrubsole
    • , Xiao-Ou Shu
    • , Ann Smeets
    • , Christof Sohn
    • , Melissa C. Southey
    • , John J. Spinelli
    • , Christa Stegmaier
    • , Sarah Stewart-Brown
    • , Jennifer Stone
    • , Daniel O. Stram
    • , Harald Surowy
    • , Anthony Swerdlow
    • , Rulla Tamimi
    • , Jack A. Taylor
    • , Maria Tengström
    • , Soo H. Teo
    • , Mary Beth Terry
    • , Daniel C. Tessier
    • , Somchai Thanasitthichai
    • , Kathrin Thöne
    • , Rob A. E. M. Tollenaar
    • , Ian Tomlinson
    • , Ling Tong
    • , Diana Torres
    • , Thérèse Truong
    • , Chiu-Chen Tseng
    • , Shoichiro Tsugane
    • , Hans-Ulrich Ulmer
    • , Giske Ursin
    • , Michael Untch
    • , Celine Vachon
    • , Christi J. van Asperen
    • , David Van Den Berg
    • , Ans M. W. van den Ouweland
    • , Lizet van der Kolk
    • , Rob B. van der Luijt
    • , Daniel Vincent
    • , Jason Vollenweider
    • , Quinten Waisfisz
    • , Shan Wang-Gohrke
    • , Clarice R. Weinberg
    • , Camilla Wendt
    • , Alice S. Whittemore
    • , Hans Wildiers
    • , Walter Willett
    • , Robert Winqvist
    • , Alicja Wolk
    • , Anna H. Wu
    • , Lucy Xia
    • , Taiki Yamaji
    • , Xiaohong R. Yang
    • , Cheng Har Yip
    • , Keun-Young Yoo
    • , Jyh-Cherng Yu
    • , Wei Zheng
    • , Ying Zheng
    • , Bin Zhu
    • , Argyrios Ziogas
    • , Elad Ziv
    • , ABCTB Investigators
    • , ConFab/AOCS Investigators
    • , Sunil R. Lakhani
    • , Antonis C. Antoniou
    • , Arnaud Droit
    • , Irene L. Andrulis
    • , Christopher I. Amos
    • , Fergus J. Couch
    • , Paul D. P. Pharoah
    • , Jenny Chang-Claude
    • , Per Hall
    • , David J. Hunter
    • , Roger L. Milne
    • , Montserrat García-Closas
    • , Marjanka K. Schmidt
    • , Stephen J. Chanock
    • , Alison M. Dunning
    • , Stacey L. Edwards
    • , Gary D. Bader
    • , Georgia Chenevix-Trench
    • , Jacques Simard
    • , Peter Kraft
    •  & Douglas F. Easton
  • Research |

    Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

    • Roger L Milne
    • , Karoline B Kuchenbaecker
    • , Kyriaki Michailidou
    • , Jonathan Beesley
    • , Siddhartha Kar
    • , Sara Lindström
    • , Shirley Hui
    • , Audrey Lemaçon
    • , Penny Soucy
    • , Joe Dennis
    • , Xia Jiang
    • , Asha Rostamianfar
    • , Hilary Finucane
    • , Manjeet K Bolla
    • , Lesley McGuffog
    • , Qin Wang
    • , Cora M Aalfs
    • , ABCTB Investigators
    • , Marcia Adams
    • , Julian Adlard
    • , Simona Agata
    • , Shahana Ahmed
    • , Habibul Ahsan
    • , Kristiina Aittomäki
    • , Fares Al-Ejeh
    • , Jamie Allen
    • , Christine B Ambrosone
    • , Christopher I Amos
    • , Irene L Andrulis
    • , Hoda Anton-Culver
    • , Natalia N Antonenkova
    • , Volker Arndt
    • , Norbert Arnold
    • , Kristan J Aronson
    • , Bernd Auber
    • , Paul L Auer
    • , Margreet G E M Ausems
    • , Jacopo Azzollini
    • , François Bacot
    • , Judith Balmaña
    • , Monica Barile
    • , Laure Barjhoux
    • , Rosa B Barkardottir
    • , Myrto Barrdahl
    • , Daniel Barnes
    • , Daniel Barrowdale
    • , Caroline Baynes
    • , Matthias W Beckmann
    • , Javier Benitez
    • , Marina Bermisheva
    • , Leslie Bernstein
    • , Yves-Jean Bignon
    • , Kathleen R Blazer
    • , Marinus J Blok
    • , Carl Blomqvist
    • , William Blot
    • , Kristie Bobolis
    • , Bram Boeckx
    • , Natalia V Bogdanova
    • , Anders Bojesen
    • , Stig E Bojesen
    • , Bernardo Bonanni
    • , Anne-Lise Børresen-Dale
    • , Aniko Bozsik
    • , Angela R Bradbury
    • , Judith S Brand
    • , Hiltrud Brauch
    • , Hermann Brenner
    • , Brigitte Bressac-de Paillerets
    • , Carole Brewer
    • , Louise Brinton
    • , Per Broberg
    • , Angela Brooks-Wilson
    • , Joan Brunet
    • , Thomas Brüning
    • , Barbara Burwinkel
    • , Saundra S Buys
    • , Jinyoung Byun
    • , Qiuyin Cai
    • , Trinidad Caldés
    • , Maria A Caligo
    • , Ian Campbell
    • , Federico Canzian
    • , Olivier Caron
    • , Angel Carracedo
    • , Brian D Carter
    • , J Esteban Castelao
    • , Laurent Castera
    • , Virginie Caux-Moncoutier
    • , Salina B Chan
    • , Jenny Chang-Claude
    • , Stephen J Chanock
    • , Xiaoqing Chen
    • , Ting-Yuan David Cheng
    • , Jocelyne Chiquette
    • , Hans Christiansen
    • , Kathleen B M Claes
    • , Christine L Clarke
    • , Thomas Conner
    • , Don M Conroy
    • , Jackie Cook
    • , Emilie Cordina-Duverger
    • , Sten Cornelissen
    • , Isabelle Coupier
    • , Angela Cox
    • , David G Cox
    • , Simon S Cross
    • , Katarina Cuk
    • , Julie M Cunningham
    • , Kamila Czene
    • , Mary B Daly
    • , Francesca Damiola
    • , Hatef Darabi
    • , Rosemarie Davidson
    • , Kim De Leeneer
    • , Peter Devilee
    • , Ed Dicks
    • , Orland Diez
    • , Yuan Chun Ding
    • , Nina Ditsch
    • , Kimberly F Doheny
    • , Susan M Domchek
    • , Cecilia M Dorfling
    • , Thilo Dörk
    • , Isabel dos-Santos-Silva
    • , Stéphane Dubois
    • , Pierre-Antoine Dugué
    • , Martine Dumont
    • , Alison M Dunning
    • , Lorraine Durcan
    • , Miriam Dwek
    • , Bernd Dworniczak
    • , Diana Eccles
    • , Ros Eeles
    • , Hans Ehrencrona
    • , Ursula Eilber
    • , Bent Ejlertsen
    • , Arif B Ekici
    • , A Heather Eliassen
    • , EMBRACE
    • , Christoph Engel
    • , Mikael Eriksson
    • , Laura Fachal
    • , Laurence Faivre
    • , Peter A Fasching
    • , Ulrike Faust
    • , Jonine Figueroa
    • , Dieter Flesch-Janys
    • , Olivia Fletcher
    • , Henrik Flyger
    • , William D Foulkes
    • , Eitan Friedman
    • , Lin Fritschi
    • , Debra Frost
    • , Marike Gabrielson
    • , Pragna Gaddam
    • , Marilie D Gammon
    • , Patricia A Ganz
    • , Susan M Gapstur
    • , Judy Garber
    • , Vanesa Garcia-Barberan
    • , José A García-Sáenz
    • , Mia M Gaudet
    • , Marion Gauthier-Villars
    • , Andrea Gehrig
    • , GEMO Study Collaborators
    • , Vassilios Georgoulias
    • , Anne-Marie Gerdes
    • , Graham G Giles
    • , Gord Glendon
    • , Andrew K Godwin
    • , Mark S Goldberg
    • , David E Goldgar
    • , Anna González-Neira
    • , Paul Goodfellow
    • , Mark H Greene
    • , Grethe I Grenaker Alnæs
    • , Mervi Grip
    • , Jacek Gronwald
    • , Anne Grundy
    • , Daphne Gschwantler-Kaulich
    • , Pascal Guénel
    • , Qi Guo
    • , Lothar Haeberle
    • , Eric Hahnen
    • , Christopher A Haiman
    • , Niclas Håkansson
    • , Emily Hallberg
    • , Ute Hamann
    • , Nathalie Hamel
    • , Susan Hankinson
    • , Thomas V O Hansen
    • , Patricia Harrington
    • , Steven N Hart
    • , Jaana M Hartikainen
    • , Catherine S Healey
    • , HEBON
    • , Alexander Hein
    • , Sonja Helbig
    • , Alex Henderson
    • , Jane Heyworth
    • , Belynda Hicks
    • , Peter Hillemanns
    • , Shirley Hodgson
    • , Frans B Hogervorst
    • , Antoinette Hollestelle
    • , Maartje J Hooning
    • , Bob Hoover
    • , John L Hopper
    • , Chunling Hu
    • , Guanmengqian Huang
    • , Peter J Hulick
    • , Keith Humphreys
    • , David J Hunter
    • , Evgeny N Imyanitov
    • , Claudine Isaacs
    • , Motoki Iwasaki
    • , Louise Izatt
    • , Anna Jakubowska
    • , Paul James
    • , Ramunas Janavicius
    • , Wolfgang Janni
    • , Uffe Birk Jensen
    • , Esther M John
    • , Nichola Johnson
    • , Kristine Jones
    • , Michael Jones
    • , Arja Jukkola-Vuorinen
    • , Rudolf Kaaks
    • , Maria Kabisch
    • , Katarzyna Kaczmarek
    • , Daehee Kang
    • , Karin Kast
    • , kConFab/AOCS Investigators
    • , Renske Keeman
    • , Michael J Kerin
    • , Carolien M Kets
    • , Machteld Keupers
    • , Sofia Khan
    • , Elza Khusnutdinova
    • , Johanna I Kiiski
    • , Sung-Won Kim
    • , Julia A Knight
    • , Irene Konstantopoulou
    • , Veli-Matti Kosma
    • , Vessela N Kristensen
    • , Torben A Kruse
    • , Ava Kwong
    • , Anne-Vibeke Lænkholm
    • , Yael Laitman
    • , Fiona Lalloo
    • , Diether Lambrechts
    • , Keren Landsman
    • , Christine Lasset
    • , Conxi Lazaro
    • , Loic Le Marchand
    • , Julie Lecarpentier
    • , Andrew Lee
    • , Eunjung Lee
    • , Jong Won Lee
    • , Min Hyuk Lee
    • , Flavio Lejbkowicz
    • , Fabienne Lesueur
    • , Jingmei Li
    • , Jenna Lilyquist
    • , Anne Lincoln
    • , Annika Lindblom
    • , Jolanta Lissowska
    • , Wing-Yee Lo
    • , Sibylle Loibl
    • , Jirong Long
    • , Jennifer T Loud
    • , Jan Lubinski
    • , Craig Luccarini
    • , Michael Lush
    • , Robert J MacInnis
    • , Tom Maishman
    • , Enes Makalic
    • , Ivana Maleva Kostovska
    • , Kathleen E Malone
    • , Siranoush Manoukian
    • , JoAnn E Manson
    • , Sara Margolin
    • , John W M Martens
    • , Maria Elena Martinez
    • , Keitaro Matsuo
    • , Dimitrios Mavroudis
    • , Sylvie Mazoyer
    • , Catriona McLean
    • , Hanne Meijers-Heijboer
    • , Primitiva Menéndez
    • , Jeffery Meyer
    • , Hui Miao
    • , Austin Miller
    • , Nicola Miller
    • , Gillian Mitchell
    • , Marco Montagna
    • , Kenneth Muir
    • , Anna Marie Mulligan
    • , Claire Mulot
    • , Sue Nadesan
    • , Katherine L Nathanson
    • , NBSC Collaborators
    • , Susan L Neuhausen
    • , Heli Nevanlinna
    • , Ines Nevelsteen
    • , Dieter Niederacher
    • , Sune F Nielsen
    • , Børge G Nordestgaard
    • , Aaron Norman
    • , Robert L Nussbaum
    • , Edith Olah
    • , Olufunmilayo I Olopade
    • , Janet E Olson
    • , Curtis Olswold
    • , Kai-ren Ong
    • , Jan C Oosterwijk
    • , Nick Orr
    • , Ana Osorio
    • , V Shane Pankratz
    • , Laura Papi
    • , Tjoung-Won Park-Simon
    • , Ylva Paulsson-Karlsson
    • , Rachel Lloyd
    • , Inge Søkilde Pedersen
    • , Bernard Peissel
    • , Ana Peixoto
    • , Jose I A Perez
    • , Paolo Peterlongo
    • , Julian Peto
    • , Georg Pfeiler
    • , Catherine M Phelan
    • , Mila Pinchev
    • , Dijana Plaseska-Karanfilska
    • , Bruce Poppe
    • , Mary E Porteous
    • , Ross Prentice
    • , Nadege Presneau
    • , Darya Prokofieva
    • , Elizabeth Pugh
    • , Miquel Angel Pujana
    • , Katri Pylkäs
    • , Brigitte Rack
    • , Paolo Radice
    • , Nazneen Rahman
    • , Johanna Rantala
    • , Christine Rappaport-Fuerhauser
    • , Gad Rennert
    • , Hedy S Rennert
    • , Valerie Rhenius
    • , Kerstin Rhiem
    • , Andrea Richardson
    • , Gustavo C Rodriguez
    • , Atocha Romero
    • , Jane Romm
    • , Matti A Rookus
    • , Anja Rudolph
    • , Thomas Ruediger
    • , Emmanouil Saloustros
    • , Joyce Sanders
    • , Dale P Sandler
    • , Suleeporn Sangrajrang
    • , Elinor J Sawyer
    • , Daniel F Schmidt
    • , Minouk J Schoemaker
    • , Fredrick Schumacher
    • , Peter Schürmann
    • , Lukas Schwentner
    • , Christopher Scott
    • , Rodney J Scott
    • , Sheila Seal
    • , Leigha Senter
    • , Caroline Seynaeve
    • , Mitul Shah
    • , Priyanka Sharma
    • , Chen-Yang Shen
    • , Xin Sheng
    • , Hermela Shimelis
    • , Martha J Shrubsole
    • , Xiao-Ou Shu
    • , Lucy E Side
    • , Christian F Singer
    • , Christof Sohn
    • , Melissa C Southey
    • , John J Spinelli
    • , Amanda B Spurdle
    • , Christa Stegmaier
    • , Dominique Stoppa-Lyonnet
    • , Grzegorz Sukiennicki
    • , Harald Surowy
    • , Christian Sutter
    • , Anthony Swerdlow
    • , Csilla I Szabo
    • , Rulla M Tamimi
    • , Yen Y Tan
    • , Jack A Taylor
    • , Maria-Isabel Tejada
    • , Maria Tengström
    • , Soo H Teo
    • , Mary B Terry
    • , Daniel C Tessier
    • , Alex Teulé
    • , Kathrin Thöne
    • , Darcy L Thull
    • , Maria Grazia Tibiletti
    • , Laima Tihomirova
    • , Marc Tischkowitz
    • , Amanda E Toland
    • , Rob A E M Tollenaar
    • , Ian Tomlinson
    • , Ling Tong
    • , Diana Torres
    • , Martine Tranchant
    • , Thérèse Truong
    • , Kathy Tucker
    • , Nadine Tung
    • , Jonathan Tyrer
    • , Hans-Ulrich Ulmer
    • , Celine Vachon
    • , Christi J van Asperen
    • , David Van Den Berg
    • , Ans M W van den Ouweland
    • , Elizabeth J van Rensburg
    • , Liliana Varesco
    • , Raymonda Varon-Mateeva
    • , Ana Vega
    • , Alessandra Viel
    • , Joseph Vijai
    • , Daniel Vincent
    • , Jason Vollenweider
    • , Lisa Walker
    • , Zhaoming Wang
    • , Shan Wang-Gohrke
    • , Barbara Wappenschmidt
    • , Clarice R Weinberg
    • , Jeffrey N Weitzel
    • , Camilla Wendt
    • , Jelle Wesseling
    • , Alice S Whittemore
    • , Juul T Wijnen
    • , Walter Willett
    • , Robert Winqvist
    • , Alicja Wolk
    • , Anna H Wu
    • , Lucy Xia
    • , Xiaohong R Yang
    • , Drakoulis Yannoukakos
    • , Daniela Zaffaroni
    • , Wei Zheng
    • , Bin Zhu
    • , Argyrios Ziogas
    • , Elad Ziv
    • , Kristin K Zorn
    • , Manuela Gago-Dominguez
    • , Arto Mannermaa
    • , Håkan Olsson
    • , Manuel R Teixeira
    • , Jennifer Stone
    • , Kenneth Offit
    • , Laura Ottini
    • , Sue K Park
    • , Mads Thomassen
    • , Per Hall
    • , Alfons Meindl
    • , Rita K Schmutzler
    • , Arnaud Droit
    • , Gary D Bader
    • , Paul D P Pharoah
    • , Fergus J Couch
    • , Douglas F Easton
    • , Peter Kraft
    • , Georgia Chenevix-Trench
    • , Montserrat García-Closas
    • , Marjanka K Schmidt
    • , Antonis C Antoniou
    •  & Jacques Simard
  • Research |

    Liu et al. find that PKM2 methylated by CARM1 inhibits Ca2+ influx from endoplasmic reticulum to mitochondria, thus restraining mitochondrial oxidative phosphorylation while promoting aerobic glycolysis and breast cancer growth.

    • Fabao Liu
    • , Fengfei Ma
    • , Yuyuan Wang
    • , Ling Hao
    • , Hao Zeng
    • , Chenxi Jia
    • , Yidan Wang
    • , Peng Liu
    • , Irene M. Ong
    • , Baobin Li
    • , Guojun Chen
    • , Jiaoyang Jiang
    • , Shaoqin Gong
    • , Lingjun Li
    •  & Wei Xu
  • Research | | open

    Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS inhibition.

    • Mandar Deepak Muzumdar
    • , Pan-Yu Chen
    • , Kimberly Judith Dorans
    • , Katherine Minjee Chung
    • , Arjun Bhutkar
    • , Erin Hong
    • , Elisa M. Noll
    • , Martin R. Sprick
    • , Andreas Trumpp
    •  & Tyler Jacks
  • Research | | open

    It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.

    • S. Intidhar Labidi-Galy
    • , Eniko Papp
    • , Dorothy Hallberg
    • , Noushin Niknafs
    • , Vilmos Adleff
    • , Michael Noe
    • , Rohit Bhattacharya
    • , Marian Novak
    • , Siân Jones
    • , Jillian Phallen
    • , Carolyn A. Hruban
    • , Michelle S. Hirsch
    • , Douglas I. Lin
    • , Lauren Schwartz
    • , Cecile L. Maire
    • , Jean-Christophe Tille
    • , Michaela Bowden
    • , Ayse Ayhan
    • , Laura D. Wood
    • , Robert B. Scharpf
    • , Robert Kurman
    • , Tian-Li Wang
    • , Ie-Ming Shih
    • , Rachel Karchin
    • , Ronny Drapkin
    •  & Victor E. Velculescu

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