In this study, Oaks and Patel et al. characterize the crosstalk between the pentose phosphate pathway and mitochondrial redox homeostasis in the context of aldose reductase and transaldolase deficiency and the contribution of pentose phosphate pathway mitochondria deregulation to the progression from cirrhosis to hepatocellular carcinoma.
Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model
MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer
Phosphorylation of UHRF2 affects malignant phenotypes of HCC and HBV replication by blocking DHX9 ubiquitylation
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis
Multimodality annotated hepatocellular carcinoma data set including pre- and post-TACE with imaging segmentation
Recurrent germline variant in ATM associated with familial myeloproliferative neoplasms
Phenotypic correlations of CALR mutation variant allele frequency in patients with myelofibrosis
Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia
The KRASG12D inhibitor MRTX1133 elucidates KRAS-mediated oncogenesis
Potential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies