Featured
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Letter |
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes
Mutations in the transcription factor FOXA1 that are common in prostate cancer result in gain-of-function effects that promote changes in the differentiation of tumour cells.
- Elizabeth J. Adams
- , Wouter R. Karthaus
- & Charles L. Sawyers
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Letter |
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
DNA damage induces translocation of cyclic GMP–AMP synthase to the nucleus, where it suppresses homologous recombination by interfering with the formation of the PARP1–Timeless complex.
- Haipeng Liu
- , Haiping Zhang
- & Baoxue Ge
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Article |
Precancerous neoplastic cells can move through the pancreatic ductal system
Comparison of multiple lesions from individual pancreases sheds light on how ancestral clones can spread through the ductal system and give rise to precursor lesions, with acquisition of further mutations leading to pancreatic cancer.
- Alvin P. Makohon-Moore
- , Karen Matsukuma
- & Christine A. Iacobuzio-Donahue
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Article
| Open AccessThe landscape of genomic alterations across childhood cancers
Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.
- Susanne N. Gröbner
- , Barbara C. Worst
- & Stefan M. Pfister
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Letter |
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition
Combined studies in MYC-driven mouse lymphomas and human Burkitt lymphoma unravel an essential role for the B-cell antigen receptor in the control of tumour B-cell fitness both in vitro and in vivo, with possible biological and clinical implications.
- Gabriele Varano
- , Simon Raffel
- & Stefano Casola
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Letter |
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
Mutations in the protein tyrosine phosphatase SHP2 affect cells in the bone marrow environment, which leads to aberrant activation of resident haematopoietic stem cells and thereby contributes to the development of leukaemia.
- Lei Dong
- , Wen-Mei Yu
- & Cheng-Kui Qu
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Article |
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
- Bernard Thienpont
- , Jessica Steinbacher
- & Diether Lambrechts
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Article |
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
A high-fat diet increases the number of intestinal stem cells in mammals, both in vivo and in intestinal organoids; a pathway that involves PPAR-δ confers organoid-initiating capacity to non-stem cells and induces them to form in vivo tumours after loss of the Apc tumour suppressor.
- Semir Beyaz
- , Miyeko D. Mana
- & Ömer H. Yilmaz
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Letter |
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling
Deletion of Ptpn11 in a newly defined mesenchymal progenitor population in the perichondral groove of Ranvier leads to metachondromatosis by increasing Indian hedgehog expression and activating hedgehog signalling, a process that can be reversed with the use of hedgehog pathway inhibitors.
- Wentian Yang
- , Jianguo Wang
- & Benjamin G. Neel
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Letter |
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
A cell-autonomous role for the COUP-TFII transcription factor in prostate cancer cells is identified, in which COUP-TFII inhibits TGF-β signalling by binding to SMAD4; COUP-TFII promotes prostate tumorigenesis and metastasis in a mouse model, and is associated with more aggressive disease in human prostate cancers.
- Jun Qin
- , San-Pin Wu
- & Sophia Y. Tsai
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Letter |
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
Individuals with the red hair/fair skin phenotype usually carry a polymorphism in the gene encoding the melanocortin 1 receptor (Mc1r) that results in the production of pigment containing a high pheomelanin-to-eumelanin ratio; here it is shown in a mouse model that inactivation of Mc1r promotes melanoma formation in the presence of the Braf oncogene, thus suggesting that pheomelanin synthesis is carcinogenic by an ultraviolet-radiation-independent mechanism.
- Devarati Mitra
- , Xi Luo
- & David E. Fisher
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News & Views |
Destiny from density
The identification of a signalling protein that regulates the accumulation of fat and connective tissue in breasts may help to explain why high mammographic density is linked to breast-cancer risk. It may also provide a marker for predicting this risk.
- Victoria L. Seewaldt
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Letter |
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via the NLRP3 and NLRP6 inflammasomes provides an unanticipated mechanism, controlling IL-22 and thereby the development of colon cancer.
- Samuel Huber
- , Nicola Gagliani
- & Richard A. Flavell
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News & Views |
When more is less
A tightly regulated enzyme balances energy production and the synthesis of macromolecules from glucose in cancer cells. Upsetting this balance by stimulating the enzyme's activity can suppress tumour growth in mice.
- Lei Jiang
- & Ralph J. DeBerardinis
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Letter |
DCC constrains tumour progression via its dependence receptor activity
A mouse model is developed in which the pro-apoptotic activity of DCC is silenced and the mice are more prone to intestinal tumour progression, giving insight into the role of DCC in human colorectal cancer.
- Marie Castets
- , Laura Broutier
- & Patrick Mehlen
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Letter |
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
- Weiwei Yang
- , Yan Xia
- & Zhimin Lu
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Letter |
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Tumour cells with defective mitochondria are found to use glutamine-dependent reductive carboxylation, rather than oxidative metabolism, as the major pathway of citrate and lipid formation.
- Andrew R. Mullen
- , William W. Wheaton
- & Ralph J. DeBerardinis
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Review Article |
A continuum model for tumour suppression
- Alice H. Berger
- , Alfred G. Knudson
- & Pier Paolo Pandolfi
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Letter |
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- Gina M. DeNicola
- , Florian A. Karreth
- & David A. Tuveson
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Letter |
COP1 is a tumour suppressor that causes degradation of ETS transcription factors
- Alberto C. Vitari
- , Kevin G. Leong
- & Vishva M. Dixit
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News & Views |
When catastrophe strikes a cell
In 2–3% of cancers, a single genetic event may have led to hundreds of genomic rearrangements confined to just one or a few chromosomes. This finding challenges the conventional view of how mutations accumulate in oncogenesis.
- Jose M. C. Tubio
- & Xavier Estivill
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Letter |
Oncogenically active MYD88 mutations in human lymphoma
This study finds frequent mutations in MYD88 in the activated B-cell-like subtype of diffuse large B-cell lymphoma and, with lower frequency, in mucosa-associated lymphoid tissue lymphomas. MYD88 mediates signalling by Toll-like receptors, and the mutations, most of which affect the same amino acid, are shown to activate the pathway and promote cancer cell survival.
- Vu N. Ngo
- , Ryan M. Young
- & Louis M. Staudt
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Letter |
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
Progestins, used in hormone replacement therapy and contraceptives, have been suggested to promote the development of breast cancer. These authors show that the ability of progestins to induce mammary tumours in mouse models is mediated by RANKL (receptor activator of NF-KB ligand). Inhibition of RANKL could reduce tumorigenesis in hormone-induced and other mouse mammary gland tumour models, suggesting a new therapeutic approach.
- Eva Gonzalez-Suarez
- , Allison P. Jacob
- & William C. Dougall
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Article |
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Cellular senescence — an irreversible cell-cycle arrest — has been implicated in suppressing tumour formation or growth. A new cellular signalling pathway that drives senescence has now been identified. This pathway does not involve most known mediators of senescence, and instead signals via the proteins Atf4, p27 and p21. Inactivating the proto-oncogene Skp2 in the context of oncogenic signalling can induce senescence through this new pathway, indicating that drugs that target Skp2 might be useful in cancer treatment.
- Hui-Kuan Lin
- , Zhenbang Chen
- & Pier Paolo Pandolfi
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Letter |
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
In response to oncogenic stress, the tumour suppressor ARF activates the p53 protein. ARF protein is highly stable in most human cell lines, so it has been thought that ARF activation occurs mainly at the level of transcription. Here, however, ARF is shown to be unstable in normal human cells but stable in cancer cells, through a transcription-independent mechanism. A ubiquitin ligase for ARF is identified and shown to promote ARF degradation in normal cells. This activity is prevented in cancer cells, stabilizing ARF.
- Delin Chen
- , Jing Shan
- & Wei Gu
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Research Highlights |
Cancer biology: Weighted cancer risk
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Letter |
Interaction between RasV12 and scribbled clones induces tumour growth and invasion
In human tumours, complex cell interactions in the tumour and its microenvironment are thought to have an important role in tumorigenesis and cancer progression. In a genetically well-defined model system in Drosophila, clones of cells bearing different mutations are now shown to cooperate to promote tumour growth and invasion. This interaction involves JNK signalling propagation and JNK-induced upregulation of JAK/STAT-activating cytokines.
- Ming Wu
- , José Carlos Pastor-Pareja
- & Tian Xu