An oncogene is a gene that will transform a cell in culture. Oncogenes were initially identified in cancer-causing retroviruses. Genes involved in the regulation of cell division, movement and signalling for example can function as oncogenes under specific conditions.

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News and Comment

  • Research Highlights |

    Using a rapid mass-spectrometry based approach to analyse aerosol released during surgical cauterization of tumour tissue, Koundouros et al. derived metabolic signatures associated with the tumour genotype. Based on these signatures, they identified a new mechanism by which oncogenic PI3K signalling promotes tumour growth.

    • Ulrike Harjes
  • Research Highlights |

    Yoshida, Gowers et al. examined somatic mutations in normal lung epithelium to better understand the effects of tobacco smoking, and stopping smoking, on normal tissue biology and how these effects relate to lung cancer development.

    • Sarah Seton-Rogers
  • News and Views |

    The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.

    • Thomas P. Burris
  • Comments and Opinion |

    As more patients with oncogene-driven non-small-cell lung cancer are treated with targeted therapies, they are joining forces online to form groups that provide support, education and advocacy focused on specific oncogenes. Herein, we discuss how the involvement of these groups in patient-partnered research can benefit both patients and lung cancer research.

    • Merel Hennink
    • , Geert Vandeweyer
    •  & Janet Freeman-Daily