Oncogene proteins
Oncogene proteins are proteins encoded by oncogenes (dysregulated or activated genes) and have a potential to cause cancer. Transcription factors, kinases and growth factors are considered oncogene proteins as they are generically involved in signalling systems leading to cell growth, survival, differentiation and programmed cell death (apoptosis).
Latest Research and Reviews
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Research
| Open Access
Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors
Nature Communications 13, 1087 -
Research |
Mechanism for the activation of the anaplastic lymphoma kinase receptor
Nature 600, 153-157 -
Research
| Open Access
The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core
Nature Communications 12, 4932 -
Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy
Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas
Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors
Mechanism for the activation of the anaplastic lymphoma kinase receptor
The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core
Rapid signaling reactivation after targeted BRAF inhibition predicts the proliferation of individual melanoma cells from an isogenic population
MYC in TOP shape
PTEN S-nitrosylation by NOS1 inhibits autophagy in NPC cells
DKK3 loss induces opposing effects
Let K-Ras activate its own inhibitor
Bcl-2 on the brink of breakthroughs in cancer treatment