Oligodendrocyte articles within Nature Communications

Featured

• Article
  19 February 2024 | Open Access

  Regulation of stress granule formation in human oligodendrocytes

  Oligodendrocyte (OL) injury and loss is a pathologic hallmark of multiple sclerosis. Here, the authors show the presence of stress granules in OLs in multiple sclerosis lesions, and their in vitro studies in human OLs indicate that stress granules formation is a response to a combination of metabolic stress and pro-inflammatory conditions.

  • Florian Pernin
  • , Qiao-Ling Cui
  •  & Jack P. Antel

• Article
  04 January 2024 | Open Access

  Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension

  The cell biological mechanisms that govern myelin sheath extension remain incompletely understood. Here, the authors find that calcium signaling in oligodendrocytes is required for the actin-dependent extension of myelin sheaths.

  • Manasi Iyer
  • , Husniye Kantarci
  •  & J. Bradley Zuchero

• Article
  08 December 2023 | Open Access

  Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex

  How oligodendrocyte precursor cells (OPCs) integrate calcium signals and neuromodulatory cues to regulate fate is unclear. Here, the authors report that locomotion-induced norepinephrine release modulates OPC calcium dynamics and differentiation.

  • Frederic Fiore
  • , Khaleel Alhalaseh
  •  & Amit Agarwal

• Article
  05 July 2023 | Open Access

  The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

  Niemann-Pick type C disease is characterized by deficiency of the endolysosomal cholesterol transporter NPC1. Here, the authors show in Npc1^−/− mice that loss of NPC1 impairs oligodendrocyte lineage cell differentiation and developmental myelination through perturbed epigenetic regulation.

  • Thaddeus J. Kunkel
  • , Alice Townsend
  •  & Andrew P. Lieberman

• Article
  08 June 2023 | Open Access

  Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

  The mechanisms regulating central nervous system remyelination efficiency are poorly understood. Here, the authors show that remyelination is driven by astrocytes supporting oligodendrocyte survival, regulated by the Nrf2 and cholesterol pathways.

  • Irene Molina-Gonzalez
  • , Rebecca K. Holloway
  •  & Veronique E. Miron

• Article
  13 February 2023 | Open Access

  Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice

  Oligodendrocytes have been increasingly shown to be involved in Alzheimer’s disease (AD). Here, the authors perform single-cell RNA-sequencing on APP NL-G-F mice and describe a disease-associated oligodendrocyte (DAO) population. They find inhibition of Erk1/2 signaling in DAOs rescues impaired axonal myelination and cognitive decline in an AD mouse model.

  • Hanseul Park
  • , Byounggook Cho
  •  & Jongpil Kim

• Article
  10 November 2022 | Open Access

  Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice

  OPC-vascular coupling contributes to myelin maintenance. Here the authors show Cav-1 stabilizes interactions and mediates OPC maturation in ischemia.

  • Ying Zhao
  • , Wusheng Zhu
  •  & Xinfeng Liu

• Article
  23 September 2022 | Open Access

  CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes

  Understanding myelination is important for CNS plasticity and disease. Here the authors show exocytosis mediated by the vesicular SNARE proteins VAMP2/3 is involved in oligodendrocyte membrane expansion.

  • Mable Lam
  • , Koji Takeo
  •  & J. Bradley Zuchero

• Article
  25 August 2022 | Open Access

  Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay

  Mutations in tRNA processing factors can lead to myelin disorders. This study shows that differentiated oligodendrocytes, cells that make the myelin, are characterized by different tRNA modifications and mRNA decay compared to their precursor cells.

  • Sophie Martin
  • , Kevin C. Allan
  •  & Jeff Coller

• Article
  15 August 2022 | Open Access

  Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

  Neonatal hypoxia leads to white matter hypomyelination due to delayed oligodendrocyte maturation. The authors identify Sirt2 as a crucial regulator of oligodendrocyte differentiation during normal white matter development and in response to hypoxia.

  • Beata Jablonska
  • , Katrina L. Adams
  •  & Vittorio Gallo

• Article
  28 April 2022 | Open Access

  Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage

  Here the authors show that, depending on their distinct developmental origins and ability to counteract oxidative stress, dorsal and ventral oligodendrocyte progenitor cells of the postnatal mouse brain are differentially vulnerable to DNA damage.

  • Enrica Boda
  • , Martina Lorenzati
  •  & Annalisa Buffo

• Article
  16 March 2022 | Open Access

  Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

  Early postnatal interruption of the bidirectional GABA/TNFSF12 signaling between parvalbumin-positive interneurons and oligodendrocyte precursor cells impairs correct prefrontal cortical network activity and social cognitive behavior later in life.

  • Li-Pao Fang
  • , Na Zhao
  •  & Xianshu Bai

• Article
  09 March 2022 | Open Access

  Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

  Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.

  • Xiao-Ru Ma
  • , Xudong Zhu
  •  & Jing-Wei Zhao

• Article
  26 August 2021 | Open Access

  Oligodendrocytic Na⁺-K⁺-Cl^– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

  Brain plasticity declines with age. Here, the authors show that NKCC1 regulates oligodendrocyte activity, facilitating neuronal plasticity during juvenile. Inducing activation of oligodendrocytic NKCC1 results in restoration of neuronal plasticity in the adult mouse brain.

  • Yoshihiko Yamazaki
  • , Yoshifumi Abe
  •  & Kenji F. Tanaka

• Article
  24 August 2021 | Open Access

  Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain

  Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelination during development and remyelination in mice.

  • Ming Zhang
  • , Jian Wang
  •  & Xianghui Zhao

• Article
  06 August 2021 | Open Access

  Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination

  Myelination patterns of different neurons in grey matter have not been fully defined. Here, the authors show that axon diameter and neuronal identity influence myelination patterns in the intact mouse somatosensory cortex. In vivo imaging revealed that remyelination altered myelin patterns but restored overall myelin content on distinct neuron subtypes.

  • Cody L. Call
  •  & Dwight E. Bergles

• Article
  07 June 2021 | Open Access

  TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice

  Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.

  • Sarah Moyon
  • , Rebecca Frawley
  •  & Patrizia Casaccia

• Article
  26 March 2021 | Open Access

  Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination

  Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.

  • Darpan Saraswat
  • , Hani J. Shayya
  •  & Fraser J. Sim

• Article
  28 January 2021 | Open Access

  Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells

  Brain myelinating oligodendrocytes are rare and difficult to isolate, which has limited data on their development. Here the authors develop a reporter for scalable purification of human pluripotent stem cell derived oligodendrocyte lineage cells, and use this to map differentiation using single cell RNA-sequencing,

  • Xitiz Chamling
  • , Alyssa Kallman
  •  & Donald J. Zack

• Article
  17 November 2020 | Open Access

  Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

  The oligodendrocyte lineage is known for its transcriptional heterogeneity, but the functional consequences of this are unclear. Here, the authors show that distinct populations of mature oligodendrocytes have spatial preferences in the brain and spinal cord and show different responses to spinal cord injury.

  • Elisa M. Floriddia
  • , Tânia Lourenço
  •  & Gonçalo Castelo-Branco

• Article
  30 October 2020 | Open Access

  A role of oligodendrocytes in information processing

  Oligodendrocytes myelinate and metabolically support axons. The role of myelination in information processing beyond regulation of conduction velocity is unclear. Here, the authors show that myelination contributes to sustained stimulus perception in the auditory cortex, shaping neuronal responses.

  • Sharlen Moore
  • , Martin Meschkat
  •  & Klaus-Armin Nave

• Article
  13 October 2020 | Open Access

  Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

  Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear. Here, the authors show that INs myelination shapes feedforward inhibition of mouse cortical sensory circuits and impacts whisker-mediated behaviour.

  • Najate Benamer
  • , Marie Vidal
  •  & María Cecilia Angulo

• Article
  29 September 2020 | Open Access

  Myelin replacement triggered by single-cell demyelination in mouse cortex

  Myelination is a highly regulated phenomenon. Here, the authors show that demyelination induced by the loss of a single oligodendrocyte triggers replenishment of a specific fraction the original myelin and myelination of previously unmyelinated axons in the mouse cortex.

  • Nicolas Snaidero
  • , Martina Schifferer
  •  & Thomas Misgeld

• Article
  09 July 2020 | Open Access

  EEF1A1 deacetylation enables transcriptional activation of remyelination

  The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and increasing remyelination efficiency.

  • Mert Duman
  • , Adrien Vaquié
  •  & Claire Jacob

• Article
  11 May 2020 | Open Access

  Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

  Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute to this behavioral phenotype.

  • Dorien A. Maas
  • , Vivian D. Eijsink
  •  & Gerard J. M. Martens

• Article
  22 October 2019 | Open Access

  Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

  It remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the paranodal axo-glial junction act jointly with molecules of the internodal domain to regulate axonal interactions and myelin wrapping, and that in the combined absence of these molecules myelin sheaths are misplaced.

  • Minou Djannatian
  • , Sebastian Timmler
  •  & Mikael Simons

• Article
  18 September 2019 | Open Access

  Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

  During cortical development the first wave of oligodendrocyte precursor cells (OPCs) completely disappear by programmed cell death, so that it is presumed that this OPC population does not play a role at postnatal stages. In this study, authors use lineage tracing in different transgenic mice to show that a subpopulation of OPCs from the first wave survives at postnatal stages and display a preferential synaptic connectivity with their ontogenetically-related interneurons compared to other OPCs or interneurons

  • David Orduz
  • , Najate Benamer
  •  & María Cecilia Angulo

• Article
  11 September 2019 | Open Access

  Oligodendrocytes express synaptic proteins that modulate myelin sheath formation

  Oligodendrocyte processes can detect and respond to axonal vesicular release. The authors here show in zebrafish that transsynaptic adhesion molecules, molecules that promote synapse formation and maturation in neurons, are expressed by oligodendrocytes and required for myelin sheath growth.

  • Alexandria N. Hughes
  •  & Bruce Appel

• Article
  13 September 2018 | Open Access

  Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells

  The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.

  • Angela M. Lager
  • , Olivia G. Corradin
  •  & Paul J. Tesar

• Article
  21 August 2018 | Open Access

  Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis

  Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.

  • Mathieu Daynac
  • , Malek Chouchane
  •  & Claudia K. Petritsch

• Article
  03 August 2018 | Open Access

  Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

  The contribution of oligodendrocytes to remyelination in functional recovery after spinal cord injury is not fully understood. Here, the authors show that oligodendrocyte progenitor cell differentiation is not required for functional recovery after spinal cord injury in mice.

  • Greg J. Duncan
  • , Sohrab B. Manesh
  •  & Wolfram Tetzlaff

• Article
  02 March 2018 | Open Access

  Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

  Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.

  • Matthias Weider
  • , Laura Julia Starost
  •  & Michael Wegner

• Article
  22 January 2018 | Open Access

  Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

  Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.

  • Stanislaw Mitew
  • , Ilan Gobius
  •  & Ben Emery

• Article
  15 September 2017 | Open Access

  Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation

  Axon-glial communication is important for myelination. Here the authors show that during postnatal development in rats, a subpopulation of pre-myelinating oligodendrocytes in the auditory brainstem receive excitatory inputs and can generate Na_v 1.2-driven action potentials, and that such process promotes myelination.

  • Emmanuelle Berret
  • , Tara Barron
  •  & Jun Hee Kim

• Article
  24 January 2017 | Open Access

  Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

  Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.

  • Stefan A. Berghoff
  • , Nina Gerndt
  •  & Gesine Saher

• Article
  19 December 2016 | Open Access

  Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury

  Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent mediator of OPC proliferation and OPC response to hypoxia.

  • Beata Jablonska
  • , Marcin Gierdalski
  •  & Vittorio Gallo

• Article
  23 November 2016 | Open Access

  VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination

  The vascular cell adhesion molecule VCAM1 plays a role in the immune system but is also expressed in oligodendrocytes. Here, the authors find VCAM1 interacts with neuronal α4 integrin to regulate oligodendrocyte differentiation and thereby myelination, an effect mediated by downstream CD69 signalling.

  • Yuki Miyamoto
  • , Tomohiro Torii
  •  & Junji Yamauchi

• Article
  15 July 2016 | Open Access

  Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

  The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.

  • Minqing Jiang
  • , Lei Liu
  •  & Q. Richard Lu

• Article
  10 May 2016 | Open Access

  Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity

  Satellite oligodendrocytes (s-OLs) are characterised by their close proximity to neocortical pyramidal cells. Here, the authors find that s-OLs myelinate axons and activity of host neurons evokes inward K⁺ currents in s-OLs which may work to modulate action potential burst firing by buffering extracellular K⁺levels.

  • Arne Battefeld
  • , Jan Klooster
  •  & Maarten H. P. Kole

• Article
  26 April 2016 | Open Access

  An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

  Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelination.

  • Michael B. Keough
  • , James A. Rogers
  •  & V. Wee Yong

• Article
  04 April 2016 | Open Access

  Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

  Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of multiple sclerosis.

  • Changsheng Du
  • , Yanhui Duan
  •  & Xin Xie

• Article
  10 March 2016 | Open Access

  G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

  The molecular mechanism controlling oligodendrocyte differentiation is not fully understood. Here the authors show that G protein coupled receptor 37 acts as a negative regulator of CNS myelination, and this effect is mediated by suppression of ERK signalling.

  • Hyun-Jeong Yang
  • , Anna Vainshtein
  •  & Elior Peles

• Article
  09 March 2016 | Open Access

  Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

  Wnt/β-catenin signaling regulates oligodendrocyte (OL) development. Here the authors show that Tcf7l2, a β-catenin transcriptional partner,sequentially interacts with stage-specific partners to coordinate the transitions of differentiation initiation and maturation during OL development.

  • Chuntao Zhao
  • , Yaqi Deng
  •  & Q. Richard Lu

• Article
  06 October 2015 | Open Access

  Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

  Myelin regeneration can occur spontaneously in demyelinating diseases but the underlying mechanisms are incompletely understood. Here the authors show that neuronal activity and glutamatergic synapses instruct oligodendrocyte progenitor cells to differentiate into new myelinating oligodendrocytes.

  • Hélène O. B. Gautier
  • , Kimberley A. Evans
  •  & Ragnhildur T Káradóttir

• Article
  04 August 2015 | Open Access

  Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

  The myelin sheath on vertebrate axons is critical for neural impulse transmission, but whether electrically active axons are preferentially myelinated by glial cells, is not clear. Here the authors show that cultured oligodendrocytes preferentially myelinate electrically active axons via a mechanism dependent on nonsynaptic vesicular release of glutamate.

  • Hiroaki Wake
  • , Fernando C. Ortiz
  •  & R. Douglas Fields

• Article
  13 March 2015 | Open Access

  Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

  Current multiple sclerosis treatments focus on prevention of immune attack on oligodendrocytes and myelin. Here the authors show a different strategy to ameliorate disease in several mouse models, protecting oligodendrocytes from inflammation-induced death with an FDA-approved drug, guanabenz.

  • Sharon W. Way
  • , Joseph R. Podojil
  •  & Brian Popko

• Article
  21 January 2015 | Open Access

  The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

  Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a specific human brain malformation and myelination defects but the cellular causes remain unclear. Here the authors show that loss of Gpr56in mice leads to decreased oligodendrocyte precursor cell proliferation and diminished levels of active RhoA.

  • Stefanie Giera
  • , Yiyu Deng
  •  & Xianhua Piao

• Article | 21 January 2015

  The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα_12/13 and RhoA

  The adhesion class of G protein-coupled receptors (aGPCRs) is essential for peripheral nervous system myelination, but functions in central nervous system myelination are less understood. Here the authors show that the aGPCR Gpr56 plays a role in the development of myelinating oligodendrocytes and that this function is mediated by Gα12/13 proteins and Rho activation.

  • Sarah D. Ackerman
  • , Cynthia Garcia
  •  & Kelly R. Monk

• Article
  01 December 2014 | Open Access

  Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

  Whether oligodendrocytes have a role in the development of chronic pain is not clear. Here the authors show that oligodendrocyte depletion causes a neuropathic pain that sets in before demyelination and is independent of immune cell activation and infiltration.

  • Simon Gritsch
  • , Jianning Lu
  •  & Rohini Kuner

• Article | 21 August 2014

  Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth factor-2

  The GTPase Arf6, expressed in the central nervous system, is implicated in neural development in vitro, but the roles it plays in vivo are unclear. Akiyama et al. show in vivothat Arf6 positively regulates oligiodendrocyte myelination via the release of the growth factor FGF-2 from hippocampal neurons.

  • Masahiro Akiyama
  • , Hiroshi Hasegawa
  •  & Yasunori Kanaho