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| Open AccessEndogenous cannabinoids in the piriform cortex tune olfactory perception
Whether and how cannabinoid type-1 receptors impact sensory functions in vivo is largely unknown. Here, authors show that their endogenous activity controls network dynamics in the olfactory piriform cortex and the ability of mice to detect odorants.
- Geoffrey Terral
- , Evan Harrell
- & Lisa Roux
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| Open AccessOlfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation
Rodents use both touch and smell to get around. This work describes how olfactory information is combined with touch perception in the cortex to guide behavior.
- Anthony Renard
- , Evan R. Harrell
- & Brice Bathellier
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| Open AccessStriatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning
Where and how the brain learns from experience is not fully understood. Here the authors use a hierarchical approach from behavioural modelling to systems fMRI to cellular coding reveals brain mechanisms for history informed updating of future predictions.
- Laurens Winkelmeier
- , Carla Filosa
- & Wolfgang Kelsch
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| Open AccessPhasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction
It is not entirely understood how network plasticity produces the coding of predicted value during stimulus-outcome learning. Here, the authors reveal a reinforcing loop in distributed limbic circuits, transforming sensory stimuli into reward prediction coding broadcasted by dopamine neurons to the brain.
- Lars-Lennart Oettl
- , Max Scheller
- & Wolfgang Kelsch
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| Open AccessOlfactory memory representations are stored in the anterior olfactory nucleus
Odours are powerful stimuli used by most organisms to guide behaviour. Here, the authors identify populations of neurons within the anterior olfactory nucleus (AON) which are necessary and sufficient for the behavioural expression of odour memory.
- Afif J. Aqrabawi
- & Jun Chul Kim
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| Open AccessHuman olfactory-auditory integration requires phase synchrony between sensory cortices
Humans integrate sensory cues across multiple modalities to guide behaviour. Here, the authors report long-range phase synchronization between auditory and olfactory cortices prior to odor arrival, in a task where sound cues predict odors.
- Guangyu Zhou
- , Gregory Lane
- & Christina Zelano
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| Open AccessHippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
Hippocampus is necessary for integrating the context with sensory cues to retrieve memory for unique episodes. Here, the authors show that inhibiting topographically organized projections from hippocampus to the anterior olfactory nucleus independently impairs spatial and temporal odour memory recall.
- Afif J. Aqrabawi
- & Jun Chul Kim
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Article
| Open AccessNrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses
Neuropilin 2 (Nrp2) is expressed by a subset of mitral cells in the postero-ventral olfactory bulb in mice. Here the authors show that Nrp2 is sufficient to instruct mitral cell targeting to the anterior part of medial amygdala that modulates olfactory-driven attractive social behaviour.
- Kasumi Inokuchi
- , Fumiaki Imamura
- & Hitoshi Sakano
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| Open AccessImmobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT
The olfactory bulb is arranged in glomeruli defined by their olfactory receptor expression. The authors identify an olfactory receptor for fox odour, TMT, and show that activation of the glomerulus expressing that receptor in mice leads to immobility, but does not lead to other fear behaviours.
- Harumi Saito
- , Hirofumi Nishizumi
- & Hitoshi Sakano
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| Open AccessTop-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
The anterior olfactory nucleus pars medialis (mAON) provides cortical feedback to the olfactory bulb, but the behavioural relevance of these projections is unknown. Here, using opto- and chemogenetic approaches, the authors find the mAON bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours.
- Afif J. Aqrabawi
- , Caleb J. Browne
- & Jun Chul Kim
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| Open AccessMolecular signatures of neural connectivity in the olfactory cortex
The piriform cortex projects to multiple brain regions involved in diverse aspects of olfactory behavior but information about the organization of these outputs is lacking. Here the authors show that piriform neurons exhibit layer specific gene expression patterns that also define distinct projection targets.
- Assunta Diodato
- , Marion Ruinart de Brimont
- & Alexander Fleischmann