Ocular hypertension articles within Nature Communications

Featured

• Article
  06 October 2023 | Open Access

  Improving model fairness in image-based computer-aided diagnosis

  Deep learning models can reflect and amplify human bias, potentially resulting inaccurate missed diagnoses. Here, the authors show that by leveraging the marginal pairwise equal opportunity, their model reduces bias in medical image classification by over 35% compared to baseline models, with minimal impact on AUC values.

  • Mingquan Lin
  • , Tianhao Li
  •  & Yifan Peng

• Article
  10 November 2022 | Open Access

  Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma

  Glaucoma is an irreversible ocular disease that may lead to vision loss. Here the authors develop a theranostic smart contact lens with an intraocular pressure sensor, a flexible drug delivery system, wireless power and communication systems and an application specific integrated circuit chip for both monitoring and control of intraocular pressure in glaucoma induced rabbits.

  • Tae Yeon Kim
  • , Jee Won Mok
  •  & Sei Kwang Hahn

• Article
  18 October 2021 | Open Access

  Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

  Primary congenital glaucoma (PCG) is characterised by increased intraocular pressure, and variants in ANGPT1, or SVEP1 have been identified as risk alleles. Here, the authors show that deletion of these genes induces glaucoma in mice, and that activation of ANGPT1-TEK signaling ameliorates disease progression in mouse models.

  • Benjamin R. Thomson
  • , Pan Liu
  •  & Susan E. Quaggin

• Article
  12 August 2021 | Open Access

  GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

  Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.

  • K. Saidas Nair
  • , Chitrangda Srivastava
  •  & Anton M. Jetten

• Article
  11 June 2018 | Open Access

  A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

  Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and LMX1B using cell line and mouse experiments.

  • Hélène Choquet
  • , Seyyedhassan Paylakhi
  •  & Eric Jorgenson

• Article
  22 September 2014 | Open Access

  Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

  Glaucoma is the most common cause of irreversible blindness worldwide. Here, the authors carry out a large meta-analysis of genetic data from individuals of European and Asian ancestry and identify 10 new loci associated with vertical cup-disc ratio, a key factor in the clinical assessment of patients with glaucoma.

  • Henriët. Springelkamp
  • , René Höhn
  •  & Christopher J. Hammond

• Article | 07 January 2014

  Wafer-scale design of lightweight and transparent electronics that wraps around hairs

  Realising flexible, lightweight and transparent electronics is a continuous challenge. Here, the authors report a process to create such transistor devices, which can be transferred onto various flexible substrates, and continue to function when wrapped around human hairs.

  • Giovanni A. Salvatore
  • , Niko Münzenrieder
  •  & Gerhard Tröster