Obesity articles from across Nature Portfolio

Obesity is a condition in which excess fat has accumulated in the body, such that it can have an adverse effect on health. Obesity is defined as a body mass index (BMI) of greater than 30 kg/m2.

Latest Research and Reviews

Research
06 June 2023 | Open Access

Assessment of gastric pouch blood supply with indocyanine green fluorescence in conversional and revisional bariatric surgery: a prospective comparative study
- Francesco Mongelli
- , Fabio Garofalo
- & Michele Marengo
Scientific Reports 13, 9152
Research
05 June 2023 | Open Access

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

This study shows that the insulinotropic actions of the dual GIPR and GLP-1R agonist, tirzepatide, depend on GIPR, and that tirzepatide has weaker activity at the mouse GIPR than murine GIP.
- Kimberley El
- , Jonathan D. Douros
- & Jonathan E. Campbell
Nature Metabolism, 1-10
Research
05 June 2023 | Open Access

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank
- Daniel E. Vosberg
- , Zdenka Pausova
- & Tomáš Paus
Scientific Reports 13, 9109
Reviews | 23 May 2023

Lipid droplet biogenesis and functions in health and disease

This Review outlines our current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stress.
- Armella Zadoorian
- , Ximing Du
- & Hongyuan Yang
Nature Reviews Endocrinology, 1-17
Research
19 May 2023 | Open Access

The association between dietary diabetic risk reduction score with anthropometric and body composition variables in overweight and obese women: a cross-sectional study
- Mehdi Karimi
- , Farideh Shiraseb
- & Khadijeh Mirzaei
Scientific Reports 13, 8130
Reviews | 18 May 2023

Child and adolescent obesity

Worldwide, the prevalence of obesity in children and adolescents remains high or is increasing. This Primer by Lister and colleagues discusses the epidemiology, mechanisms, diagnosis, prevention and management of obesity in this age group. The authors also highlight patient quality of life and areas for further research.
- Natalie B. Lister
- , Louise A. Baur
- & Martin Wabitsch
Nature Reviews Disease Primers 9, 24

All Research & Reviews

News and Comment

News | 23 May 2023

Game-changing obesity drugs go mainstream: what scientists are learning

Studies tackle who’s most likely to lose weight on the new generation of anti-obesity medications.
- Mariana Lenharo
Nature 618, 17-18
Research Highlights | 09 May 2023

Nonenzymatic prevention of insulin hyperresponsiveness by FBP1
- Felicity Tournant
Nature Reviews Endocrinology 19, 380
Research Highlights | 05 May 2023

The discovery of human monogenic obesity
- John W. R. Kincaid
Nature Reviews Endocrinology 19, 381
Research Highlights | 25 April 2023

A role for the kidney in metformin action
- Claire Greenhill
Nature Reviews Endocrinology 19, 313
News & Views | 13 April 2023

Overlooked confounding in studies of metabolite salts

Metabolites have emerged as important signalling molecules, and their biological effects are frequently investigated by treating animals and cells with solutions of commercially available metabolite salts. Such experiments require proper controls for osmolarity and the presence of counterions, as illustrated by dramatic confounding effects on energy balance in studies with sodium l-lactate.

Nature Metabolism 5, 542-543
News & Views | 30 March 2023

Urban built environments: interventions for reducing cardiometabolic risks

Cities with varied development types and green space are known to be protective for cardiometabolic health, while those with higher traffic-related pollution, access to calorie-dense food and poorer perception of safety are detrimental. These factors should be considered when planning urban developments in lower-income and middle-income countries to reduce cardiometabolic disease burden.
- Chinmoy Sarkar
- & Ka Yan Lai
Nature Reviews Endocrinology 19, 315-316