Nucleosomes articles from across Nature Portfolio

Nucleosomes are the repeating unit of chromatin, and consist of approximately 147 base pairs of DNA wrapped around eight histone protein cores to allow chromosomal DNA to be packaged into a small volume. Nucleosomes are the 'beads' in the 'bead-on-a-string' depiction of chromatin.

Latest Research and Reviews

News and Comment

  • News & Views |

    Substrate–inhibitor conjugation facilitates structural determination of the KDM2A/B-nucleosome complexes, which provides mechanistic insights into the nucleosomal H3K36 demethylation by KDM2A/B and reveals a paralog-specific nucleosome acidic patch recognition mechanism mediated by the N terminus of KDM2A but not KDM2B.

    • Huasong Ai
    •  & Lei Liu
  • News & Views |

    DiMeLo-seq leverages immunotethered DNA methyltransferases with long-read sequencing to map the locations of chromatin proteins in their natural context.

    • Kami Ahmad
    Nature Methods 19, 651-652
  • News & Views |

    High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.

    • Kanishk Jain
    •  & Brian D. Strahl
  • Research Highlights |

    Loop-seq is a high-throughput sequencing assay that measures DNA looping and can help explain how DNA bendability contributes to nucleosome organization.

    • Lei Tang
    Nature Methods 18, 121
  • Research Highlights |

    Two studies in Molecular Cell report fine-scale structural profiles of mammalian genomes using Micro-C, indicating that fine chromosomal structure is regulated by diverse transcription-related features.

    • Darren J. Burgess