Nuclear transport

While nuclear transport of small molecules happens by diffusion, that of macromolecules carrying specific recognition signals happens through nuclear pore complexes. Nuclear transport is regulated by the availability of these signals to the transport machinery, changes in the levels or modifications of the molecules to be transported.

Latest Research and Reviews

  • Reviews |

    Cellular metabolism has emerged as a major biological node governing cellular behaviour. In their review, Boon et al. explore the mechanisms that maintain nuclear metabolic compartmentalization and the regulation of epigenetics, cell fate and cell physiology by nuclear metabolism.

    • Ruben Boon
    • , Giorgia G. Silveira
    •  & Raul Mostoslavsky
  • Research
    | Open Access

    The transcriptional regulator YAP shuttles rapidly between the cytoplasm and nucleus, but whether and how dynamics such as amplitude and frequency affect target gene transcription is unclear. Here, using live imaging of endogenous YAP and target-gene transcription, the authors show that YAP-dependent signalling is encoded through rapid and concerted changes in the nucleo-cytoplasmic distribution of YAP.

    • J. Matthew Franklin
    • , Rajarshi P. Ghosh
    • , Quanming Shi
    • , Michael P. Reddick
    •  & Jan T. Liphardt
  • Research
    | Open Access

    mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins Nup153, Nup50, and Tpr, and see that Tpr interacts with the TREX-2 mRNA export complex.

    • Vasilisa Aksenova
    • , Alexandra Smith
    • , Hangnoh Lee
    • , Prasanna Bhat
    • , Caroline Esnault
    • , Shane Chen
    • , James Iben
    • , Ross Kaufhold
    • , Ka Chun Yau
    • , Carlos Echeverria
    • , Beatriz Fontoura
    • , Alexei Arnaoutov
    •  & Mary Dasso
  • Research |

    In-cell structural studies in Saccharomyces cerevisiae reveal that the configuration of the Nup159 complex is a key determinant of the mRNA export function of the nuclear pore complex, and suggest a model in which nuclear pore complexes are degraded via the autophagy machinery.

    • Matteo Allegretti
    • , Christian E. Zimmerli
    • , Vasileios Rantos
    • , Florian Wilfling
    • , Paolo Ronchi
    • , Herman K. H. Fung
    • , Chia-Wei Lee
    • , Wim Hagen
    • , Beata Turoňová
    • , Kai Karius
    • , Mandy Börmel
    • , Xiaojie Zhang
    • , Christoph W. Müller
    • , Yannick Schwab
    • , Julia Mahamid
    • , Boris Pfander
    • , Jan Kosinski
    •  & Martin Beck
    Nature, 1-5
  • Research |

    The surfactant-like protein Ki-67 mediates the clustering of chromosomes during mitotic exit, which displaces large cytoplasmic molecules from the future nuclear space and thus enables the separation of cytoplasmic and nuclear components before the nuclear envelope reforms.

    • Sara Cuylen-Haering
    • , Mina Petrovic
    • , Alberto Hernandez-Armendariz
    • , Maximilian W. G. Schneider
    • , Matthias Samwer
    • , Claudia Blaukopf
    • , Liam J. Holt
    •  & Daniel W. Gerlich
    Nature, 1-6

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