Nuclear transport

While nuclear transport of small molecules happens by diffusion, that of macromolecules carrying specific recognition signals happens through nuclear pore complexes. Nuclear transport is regulated by the availability of these signals to the transport machinery, changes in the levels or modifications of the molecules to be transported.

Latest Research and Reviews

News and Comment

  • News & Views |

    The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.

    • Stefan Petrovic
    •  & André Hoelz
    Nature Cell Biology 24, 810-812
  • Research Highlights |

    Lv, Liu, Mo and colleagues demonstrate that in pancreatic ductal adenocarcinoma cells, gasdermin E transports the transcription factor YBX1 to the nucleus, where it promotes the expression of mucins, thereby providing tumour cells with a barrier against digestive enzymes.

    • Lucia Brunello
  • News & Views |

    Nuclear pore complexes (NPCs) facilitate the fast, yet highly selective, nucleocytoplasmic transport of molecules. A recent study describes a multicolour imaging approach to chart the paths for cargo molecules through the human NPC with real-time 3D visualization of nucleocytoplasmic transport events with high spatial and temporal precision.

    • Vasilisa Aksenova
    •  & Mary Dasso