Nuclear pore complex articles from across Nature Portfolio

The nuclear pore complex mediates the selective exchange of components, including RNA, ribosomal proteins, signalling molecules and lipids between the nucleus and the cytoplasm. It is one of the largest protein complexes in the cells. Small molecules diffuse through them while larger molecules are recognised by specific components called nucleoporins to be transported through the pores.

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News and Comment

  • News & Views |

    The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.

    • Stefan Petrovic
    •  & André Hoelz
    Nature Cell Biology 24, 810-812
  • News & Views |

    Nuclear pore complexes (NPCs) facilitate the fast, yet highly selective, nucleocytoplasmic transport of molecules. A recent study describes a multicolour imaging approach to chart the paths for cargo molecules through the human NPC with real-time 3D visualization of nucleocytoplasmic transport events with high spatial and temporal precision.

    • Vasilisa Aksenova
    •  & Mary Dasso
  • News & Views |

    NUP98 is one of the most promiscuous fusion partners involved in leukemogenic chromosomal translocations, but the myriad of partners has long obfuscated the mechanism by which these fusion proteins drive leukemia. A new mass spectrometry–based approach has produced clues that suggest an entirely new model of leukemogenesis.

    • Christopher I. Slape