Nuclear organization articles from across Nature Portfolio

Nuclear organization refers to the spatial distribution of nuclear contents and components in a way that reflects or facilitates their activities. For example, chromatin or nucleoli may become more condensed or expanded in response to changes in gene expression or cellular growth rate.

Latest Research and Reviews

News and Comment

  • News & Views |

    Under conditions of stress, autophagic degradation of nuclear and nucleolar components was found to promot.e youthfulness and delay aging by preserving nuclear architecture and preventing nucleolar expansion, in somatic cells. We also found that nuclear-material autophagy serves as an essential quality-control mechanism that contributes to sustaining germline immortally.

    Nature Aging 3, 11-12
  • News & Views |

    We found that aging is accompanied by a reduction in cardiomyocyte nuclear size and increased stiffness, dependent on loss of A-type lamins. Mechanistically, age-dependent nuclear remodeling represses expression of cardiogenic transcription factors that are required for heart contractility. Preserving lamin or transcription factors delays cardiac decline.

    Nature Aging 3, 15-16
  • News & Views |

    Nuclear actin polymerization helps facilitate chromosome compartment switches that can shift damaged DNA toward a nuclear environment that is favorable for DNA repair. Yet shifting multiple broken DNA strands together can also increase the likelihood of misjoining of the DNA ends and subsequent formation of translocations.

    • Heng Li
    •  & Rachel Patton McCord
  • News & Views |

    Aging is associated with an accumulation of myeloid-biased hematopoietic stem cells with reduced regenerative potential, but the underlying mechanisms remain unclear. A study by Wendorff et al. demonstrates that inactivation of a single epigenetic regulator — the plant homeodomain factor 6 (PHF6) — transcriptionally and functionally rejuvenates mouse aged hematopoietic stem cells.

    • Arthur Flohr Svendsen
    •  & Gerald de Haan
    Nature Aging 2, 980-981